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|Title:||Response of ovary in young women experiencing laparoscopy under general anaesthesia.||Authors:||Chow, W.P.
|Issue Date:||Mar-1993||Citation:||Chow, W.P., Loganath, A., Peh, K.L., Chew, P.C., Gunasegaram, R., Ratnam, S.S. (1993-03). Response of ovary in young women experiencing laparoscopy under general anaesthesia.. Medical Journal of Malaysia 48 (1) : 56-63. ScholarBank@NUS Repository.||Abstract:||This study investigated whether changes in circulating levels of immunoreactive oestradiol-17 beta (E2), progesterone (P) and testosterone (T) occur in women at follicular (n = 18, age 25 to 39 years) and luteal (n = 17, 25 to 39 years) phases of the normal menstrual cycles, experiencing laparoscopy after intravenous sedation with general anaesthesia. The pre- and intra-operative follicular phase plasma steroid hormone concentrations were 153.5 +/- 84.3 vs 297.4 +/- 220.8 pg/ml for E2, 2.0 +/- 3.2 vs 3.3 +/- 3.8 ng/ml for P and 746.6 +/- 415.9 vs 1325.8 +/- 535.1 pg/ml for T, respectively. The corresponding luteal phase steroid levels were 259.7 +/- 120.2 vs 382.7 +/- 188.7 pg/ml, 7.0 +/- 4.8 vs 9.9 +/- 6.1 ng/ml and 819.4 +/- 355.7 vs 1703.5 +/- 1058.1 pg/ml. Using the Wilcoxon rank sum test, intra-operative hormone levels with the exception of P in the luteal phase were found to be significantly elevated (p < 0.05). The results suggest that laparoscopy under general anaesthesia evokes increased secretion of ovarian hormones, possibly via the activation of hypothalamo-pituitary-ovarian axis.||Source Title:||Medical Journal of Malaysia||URI:||http://scholarbank.nus.edu.sg/handle/10635/133790||ISSN:||03005283|
|Appears in Collections:||Staff Publications|
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