Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/133677
DC Field | Value | |
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dc.title | Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates | |
dc.contributor.author | Kottegoda, S.R. | |
dc.contributor.author | Adaikan, P.G. | |
dc.contributor.author | Karim, S.M.M. | |
dc.date.accessioned | 2016-12-20T08:38:48Z | |
dc.date.available | 2016-12-20T08:38:48Z | |
dc.date.issued | 1982-04 | |
dc.identifier.citation | Kottegoda, S.R., Adaikan, P.G., Karim, S.M.M. (1982-04). Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates. Prostaglandins, Leukotrienes and Medicine 8 (4) : 343-348. ScholarBank@NUS Repository. | |
dc.identifier.issn | 02621746 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133677 | |
dc.description.abstract | 17(S)methyl-ω-homo trans δ2 PGE1 (ONO 1206) an analogue of PGE1 was studied on vasopressin-induced ECG changes in four male monkeys and three female baboons. Bolus intravenous doses of vasopressin (0.8 I.U. to 1.0 I.U./kg) produced flattening of the T wave (2 monkeys) elevation of ST segment (1 baboon and 1 monkey) and inversion of T wave (1 baboon). Inverted T waves were also present in one baboon and one monkey prior to any drug administration. In four out of seven animals, bolus intravenous doses (5 to 15 μg/kg) of ONO 1206 reversed the ECG changes produced by vasopressin and in one animal ONO 1206 reversed the existing inverted T wave. These findings indicate that vasopressin is a suitable agent for the induction of coronary vasoconstriction in primates and that ONO 1206 is able to reverse this effect. © 1982. | |
dc.type | Article | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.description.sourcetitle | Prostaglandins, Leukotrienes and Medicine | |
dc.description.volume | 8 | |
dc.description.issue | 4 | |
dc.description.page | 343-348 | |
dc.description.coden | PLMED | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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