Please use this identifier to cite or link to this item:
https://doi.org/10.1007/s005350050300
DC Field | Value | |
---|---|---|
dc.title | Suppression of hepatitis C virus by hepatitis B virus in coinfected patients at the National University Hospital of Singapore | |
dc.contributor.author | Wang, Y.M. | |
dc.contributor.author | Ng, W.C. | |
dc.contributor.author | Lo, S.K. | |
dc.date.accessioned | 2016-12-20T08:37:44Z | |
dc.date.available | 2016-12-20T08:37:44Z | |
dc.date.issued | 1999-08 | |
dc.identifier.citation | Wang, Y.M., Ng, W.C., Lo, S.K. (1999-08). Suppression of hepatitis C virus by hepatitis B virus in coinfected patients at the National University Hospital of Singapore. Journal of Gastroenterology 34 (4) : 481-485. ScholarBank@NUS Repository. https://doi.org/10.1007/s005350050300 | |
dc.identifier.issn | 09441174 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133582 | |
dc.description.abstract | This study was carried out to compare hepatitis B virus (HBV) and hepatitis C virus (HCV) replicative states and to determine possible interference between HBV and HCV. One thousand and sixty-one consecutive patients seen at The Gastroenterology Division of the National University Hospital of Singapore between 1988 and 1995 were screened for HBV and HCV serological markers. Anti-HCV was tested using a second-generation enzyme-linked immunosorbent assay (ELISA) method. HCV-RNA was detected by a reverse-transcription polymerase chain reaction method (RT-PCR). Data were analyzed by either paired t-test or χ 2 test. Two hundred and twenty-four patients were infected with HBV alone, while 117 patients were infected with HCV only. Thirty-one patients were coinfected with HBV and HCV. HCV-RNA was detected in 104 of the 117 HCV patients (88.9%), and in 12 of 29 coinfected patients (41.4%). Serum anti-HCV levels in the coinfected patients were lower than those in the HCV-infected patients. A significant difference for anti-HCV reactivity and HCV-RNA positivity was observed between HCV-infected patients and coinfected patients (P < 0.01). In contrast, HBV-DNA and hepatitis B envelope antigen (HBeAg) positive rates were similar in HBV carriers and patients coinfected with HBV and HCV. These results show a possible interaction between HBV and HCV life cycles, and suggest that HCV replication may be negatively affected by HBV. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s005350050300 | |
dc.subject | Coinfection | |
dc.subject | Hepatitis B virus | |
dc.subject | Hepatitis C virus | |
dc.subject | Hepatitis C virus antibody | |
dc.subject | Hepatitis C virus RNA | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1007/s005350050300 | |
dc.description.sourcetitle | Journal of Gastroenterology | |
dc.description.volume | 34 | |
dc.description.issue | 4 | |
dc.description.page | 481-485 | |
dc.description.coden | JOGAE | |
dc.identifier.isiut | 000081840500009 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.