Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1534-5807(02)00409-4
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dc.titleMind bomb is a ubiquitin ligase that is essential for efficient activation of notch signaling by delta
dc.contributor.authorItoh, M.
dc.contributor.authorKim, C.-H.
dc.contributor.authorPalardy, G.
dc.contributor.authorOda, T.
dc.contributor.authorJiang, Y.-J.
dc.contributor.authorMaust, D.
dc.contributor.authorYeo, S.-Y.
dc.contributor.authorLorick, K.
dc.contributor.authorWright, G.J.
dc.contributor.authorAriza-McNaughton, L.
dc.contributor.authorWeismann, A.M.
dc.contributor.authorLewis, J.
dc.contributor.authorChandrasekharappa, S.C.
dc.contributor.authorChitnis, A.B.
dc.date.accessioned2016-12-13T05:39:40Z
dc.date.available2016-12-13T05:39:40Z
dc.date.issued2003-01-01
dc.identifier.citationItoh, M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G.J., Ariza-McNaughton, L., Weismann, A.M., Lewis, J., Chandrasekharappa, S.C., Chitnis, A.B. (2003-01-01). Mind bomb is a ubiquitin ligase that is essential for efficient activation of notch signaling by delta. Developmental Cell 4 (1) : 67-82. ScholarBank@NUS Repository. https://doi.org/10.1016/S1534-5807(02)00409-4
dc.identifier.issn15345807
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133059
dc.description.abstractLateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. These observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocytosis of the Notch extracellular domain by the signaling cell. This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S1534-5807(02)00409-4
dc.sourceScopus
dc.typeReview
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1016/S1534-5807(02)00409-4
dc.description.sourcetitleDevelopmental Cell
dc.description.volume4
dc.description.issue1
dc.description.page67-82
dc.description.codenDCEEB
dc.identifier.isiut000180862000011
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