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|Title:||Hepatitis B virus infection in Singapore||Authors:||Guan, R.||Keywords:||epidemiology
|Issue Date:||1996||Citation:||Guan, R. (1996). Hepatitis B virus infection in Singapore. Gut 38 (SUPPL. 2) : S13-S17. ScholarBank@NUS Repository.||Abstract:||Although Singapore is in an endemic region for hepatitis B infection, the hepatitis B carriage rate of 5-6% is relatively low. The highest positivity rates for hepatitis B surface antigen (HBsAg) are found in the paediatric age group, with another peak in 40-49 year olds. Studies suggest that, although perinatal transmission is an important route of infection, most children acquire the virus through horizontal transmission between family members. Viral replication continues at a high rate in young carriers and tends to slow down with increasing age. Up to 50% of hepatitis B carriers in Singapore have chronic hepatitis, shown by raised serum ALT values and liver histology, and about 10% are infected with the precore mutant virus. About 20% of carriers have cirrhosis. Among patients with HCC, up to 75% are HBsAg positive, of whom 45% are still viraemic. Mass vaccination against hepatitis B was introduced into Singapore on a voluntary basis in 1983, with compulsory vaccination of babies born to HBeAg positive mothers since 1985. The number of cases of acute hepatitis B has fallen by 60% between 1989 and 1995 although the problems of the longterm complications of chronic hepatitis B still need to be tackled.||Source Title:||Gut||URI:||http://scholarbank.nus.edu.sg/handle/10635/132889||ISSN:||00175749|
|Appears in Collections:||Staff Publications|
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