Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M800517200
DC FieldValue
dc.titleFoxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
dc.contributor.authorYalcin, S.
dc.contributor.authorZhang, X.
dc.contributor.authorLuciano, J.P.
dc.contributor.authorMungamuri, S.K.
dc.contributor.authorMarinkovic, D.
dc.contributor.authorVercherat, C.
dc.contributor.authorSarkar, A.
dc.contributor.authorGrisotto, M.
dc.contributor.authorTaneja, R.
dc.contributor.authorGhaffari, S.
dc.date.accessioned2016-12-13T05:37:07Z
dc.date.available2016-12-13T05:37:07Z
dc.date.issued2008-09-12
dc.identifier.citationYalcin, S., Zhang, X., Luciano, J.P., Mungamuri, S.K., Marinkovic, D., Vercherat, C., Sarkar, A., Grisotto, M., Taneja, R., Ghaffari, S. (2008-09-12). Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. Journal of Biological Chemistry 283 (37) : 25692-25705. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M800517200
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132836
dc.description.abstractUnchecked accumulation of reactive oxygen species (ROS) compromises maintenance of hematopoietic stem cells. Regulation of ROS by the tumor suppressor protein ataxia telangiectasia mutated (ATM) is critical for preserving the hematopoietic stem cell pool. In this study we demonstrate that the Foxo3 member of the Forkhead Box O (FoxO) family of transcription factors is essential for normal ATM expression. In addition, we show that loss of Foxo3 leads to defects in hematopoietic stem cells, and these defects result from an overaccumulation of ROS. Foxo3 suppression of ROS in hematopoietic stem cells is mediated partly by regulation of ATM expression. We identify ROS-independent modulations of ATM and p16INK4a and ROS-mediated activation of p53/p21CIP1/WAF1/Sdi1 tumor suppressor pathways as major contributors to Foxo3-null hematopoietic stem cells defects. Our studies demonstrate that Foxo3 represses ROS in part via regulation of ATM and that this repression is required for maintenance of the hematopoietic stem cell pool. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M800517200
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1074/jbc.M800517200
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume283
dc.description.issue37
dc.description.page25692-25705
dc.description.codenJBCHA
dc.identifier.isiut000259012700064
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

162
checked on May 25, 2019

WEB OF SCIENCETM
Citations

149
checked on May 15, 2019

Page view(s)

26
checked on May 25, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.