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Title: Fetal and maternal levels of lipid peroxides in term pregnancies
Authors: Rogers, M.S.
Mongelli, M. 
Tsang, K.H.
Wang, C.C.
Keywords: Lipid peroxideation
Placental transportation
Umbilical cord blood
Issue Date: 1999
Citation: Rogers, M.S., Mongelli, M., Tsang, K.H., Wang, C.C. (1999). Fetal and maternal levels of lipid peroxides in term pregnancies. Acta Obstetricia et Gynecologica Scandinavica 78 (2) : 120-124. ScholarBank@NUS Repository.
Abstract: Objective. To examine the relationships between maternal and fetal concentrations of lipid peroxides in term pregnancies before the onset of labor. Methods. Umbilical cord arterial and venous blood samples were collected from 114 singleton term pregnancies delivered by elective cesarean section. Base excess, oxygen, carbon dioxide and pH were measured in both samples and compared to identify double venous samples. Maternal venous and umbilical cord arterial and venous concentrations of organic hydroperoxides and malondialdehyde were assayed. Results. Maternal plasma malondialdehyde was, on average, double that of cord blood, whereas maternal organic hydroperoxide was only 18% higher. Maternal organic hydroperoxide was correlated with cord arterial and venous levels of organic hydroperoxide but not with pH, carbon dioxide, oxygen or base excess. Maternal malondialdehyde concentration was significantly correlated with both umbilical arterial and venous values of malondialdehyde and with arterial oxygen. Multiple regression shows that 70% of the variation in maternal malondialdehyde can be accounted for by variation in arterial and venous malondialdehyde, and arterial oxygen and base excess. A similar regression analysis with maternal organic hydroperoxide as dependant variable incorporated only umbilical arterial organic hydroperoxide concentration. Conclusion. These findings suggest that there is significant trans-placental transport of malondialdehyde from the fetal circulation.
Source Title: Acta Obstetricia et Gynecologica Scandinavica
ISSN: 00016349
Appears in Collections:Staff Publications

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