Serial measurement of serum fructosamine and glycosylated haemoglobin as indices of glycaemic control in diabetic pregnancy.

Abstract

Management of diabetic pregnancy requires objective information regarding blood glucose levels with the aim of achieving strict euglycaemia. Self-blood glucose monitoring and measurement of glycosylated haemoglobin (HbA1) are two methods widely adopted in clinical practice. Serum fructosamine assay was recently introduced as a parameter for assessing short-term glycaemic control. Our study compared serial measurement of serum fructosamine with HbA1 as indices of short-term glycaemic control in a group of diabetic pregnant women prospectively from early/mid-trimester till delivery. Patients performed self-blood glucose glucose concentration of the preceding two weeks were assessed. Our results showed that both serum fructosamine and HbA1 gave comparable information regarding short-term glycaemic control. Serum fructosamine estimation did not offer any distinct additional advantage as a retrospective index of diabetic control in the management of diabetic pregnancy.