Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131960
DC FieldValue
dc.titleRecombinant DNA hepatitis B vaccine containing pre-S components of the HBV coat protein - A preliminary study on immunogenicity
dc.contributor.authorYap, I.
dc.contributor.authorGuan, R.
dc.contributor.authorChan, S.H.
dc.date.accessioned2016-11-29T02:50:39Z
dc.date.available2016-11-29T02:50:39Z
dc.date.issued1992
dc.identifier.citationYap, I., Guan, R., Chan, S.H. (1992). Recombinant DNA hepatitis B vaccine containing pre-S components of the HBV coat protein - A preliminary study on immunogenicity. Vaccine 10 (7) : 439-442. ScholarBank@NUS Repository.
dc.identifier.issn0264410X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131960
dc.description.abstractA novel recombinant hepatitis B vaccine, trademarked Sci-B-Vac, was evaluated for safety, tolerability and immunogenicity in an open label trial performed in Singapore. The experimental vaccine, derived from Chinese hamster ovary (CHO) cells, consists of hepatitis B surface antigen (HBsAg) particles harbouring all three viral envelope polypeptides, the major S protein and the minor Pre-S2 and Pre-S1, in their glycosylated and non-glycosylated forms. The vaccine was administered intramuscularly at 0, 1 and 6 months. No unexpected adverse effects were observed. A high level anti-HBs response to Sci-B-Vac was indicative of its immunogenicity. Subsequent to the third injection, 100% and 92% of the 10 μg and 5 μg dose recipients, respectively, were seroprotected (anti-HBs titres ≥ 10 mIU ml -1). Moreover, the geometric mean titres (GMT) of the anti-HBs response were very high: 2687 and 1473 mIU ml -1, respectively. An immunogenic advantage of Sci-B-Vac was also suggested by the rapid onset of antibody response: 96% of the 10 μg dose recipients were seroprotected with a GMT of 159 mIU ml -1, prior to the third injection.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0264-410X(92)90391-V
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.sourcetitleVaccine
dc.description.volume10
dc.description.issue7
dc.description.page439-442
dc.description.codenVACCD
dc.identifier.isiutA1992HV88400003
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.