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Title: Soluble T-cell markers and serum cytokines in type I (insulin-dependent) Diabetes mellitus
Authors: Ng, W.-Y. 
Thai, A.-C.
Lui, K.-F.
Yeo, P.P.B. 
Cheah, J.-S. 
Keywords: Cytokines
Insulin-dependent diabetes mellitus
Issue Date: 1995
Citation: Ng, W.-Y., Thai, A.-C., Lui, K.-F., Yeo, P.P.B., Cheah, J.-S. (1995). Soluble T-cell markers and serum cytokines in type I (insulin-dependent) Diabetes mellitus. International Archives of Allergy and Immunology 108 (1) : 39-42. ScholarBank@NUS Repository.
Abstract: Markers of cell-mediated immune activation were studied in 32 Chinese patients with recent-onset insulin-dependent diabetes mellitus (IDDM) as compared with 12 patients with recent-onset non-insulin-dependent diabetes mellitus (NIDDM) and 34 normal subjects. Sera were assessed for soluble markers of T-cell activation (sCD4, sCD8, sIL-2R); the cytokines (IL-1β, TNF-α, IL-2, IL-6), and T-cell subsets were also determined. Only 1 of the 32 IDDM patients had increased sCD4 levels, 5 had increased sCD8, and 3 had increased sIL-2R. None of the sera from NIDDM patients and control subjects showed such increased levels of soluble markers. Three IDDM patients had detectable IL-1β and this weakly so (
Source Title: International Archives of Allergy and Immunology
ISSN: 10182438
Appears in Collections:Staff Publications

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