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Title: Obsessive compulsive disorder - A neuropsychiatric illness
Authors: Ko, S.M. 
Keywords: electrophysiology
obsessive compulsive disorder
soft signs
Issue Date: Apr-1996
Citation: Ko, S.M. (1996-04). Obsessive compulsive disorder - A neuropsychiatric illness. Singapore Medical Journal 37 (2) : 186-188. ScholarBank@NUS Repository.
Abstract: Until recently, obsessive compulsive disorder (OCD) was thought to be a rare condition. Once viewed predominantly as a manifestation of psychodynamic conflict, OCD is now considered a model neuropsychiatric disorder. While clear differences exist between OCD patients and normal controls, there are more similarities between OCD and Tourette's Syndrome than most other neurotic disorders in neurological signs, electrophysiology and neuropsychology. These include a lack of laterality, bilateral or dominant (left) frontal lobe dysfunction, shortened REM latency in sleep electroencephalogram, shortened latency of N200 and P300 components in visual evoked potentials, abnormal glucose metabolism in the caudate nucleus, and greater ventricle to brain ratios in OCD patients. Neuropharmacological and neuroendocrinological researches have increasingly shown that serotonin plays an important role in the complex aetiology in OCD. Finally, psychopharmacological trials have consistently demonstrated the effectiveness of the selective serotonin reuptake inhibitors in the treatment of OCD.
Source Title: Singapore Medical Journal
ISSN: 00375675
Appears in Collections:Staff Publications

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