Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.it.2004.06.005
Title: | IL-4 in tuberculosis: Implications for vaccine design | Authors: | Rook, G.A.W. Hernandez-Pando, R. Dheda, K. Teng Seah, G. |
Issue Date: | Sep-2004 | Citation: | Rook, G.A.W., Hernandez-Pando, R., Dheda, K., Teng Seah, G. (2004-09). IL-4 in tuberculosis: Implications for vaccine design. Trends in Immunology 25 (9) : 483-488. ScholarBank@NUS Repository. https://doi.org/10.1016/j.it.2004.06.005 | Abstract: | Current attempts to find a vaccine for tuberculosis (TB) are based on the assumption that it must drive a Th1 response. We review the evidence that progressive disease might not be due to absence of Th1, but rather to the subversive effect of an unusual Th2-like response, involving interleukin-4 (IL-4) and IL-4δ2. This Th2-like response can impair bactericidal function and lead to toxicity of tumour necrosis factor-α (TNF-α) and to pulmonary fibrosis. If this is important, effective vaccines will need to suppress pre-existing Th2-like activity. Such vaccines are feasible and are active therapeutically in mouse TB. | Source Title: | Trends in Immunology | URI: | http://scholarbank.nus.edu.sg/handle/10635/131755 | ISSN: | 14714906 | DOI: | 10.1016/j.it.2004.06.005 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
151
checked on Feb 24, 2021
WEB OF SCIENCETM
Citations
145
checked on Feb 16, 2021
Page view(s)
41
checked on Feb 27, 2021
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.