Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijcard.2007.10.022
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dc.titleHigh dose Clopidogrel decreases mice liver mitochondrial respiration function in vitro
dc.contributor.authorTAI YEE KIT
dc.contributor.authorCheong, Y.M.C.
dc.contributor.authorAlmsherqi, Z.A.
dc.contributor.authorChia, S.H.
dc.contributor.authorDeng, Y.
dc.contributor.authorMcLachlan, C.S.
dc.date.accessioned2016-11-29T01:20:19Z
dc.date.available2016-11-29T01:20:19Z
dc.date.issued2009-04-03
dc.identifier.citationTAI YEE KIT, Cheong, Y.M.C., Almsherqi, Z.A., Chia, S.H., Deng, Y., McLachlan, C.S. (2009-04-03). High dose Clopidogrel decreases mice liver mitochondrial respiration function in vitro. International Journal of Cardiology 133 (2) : 250-252. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2007.10.022
dc.identifier.issn01675273
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131580
dc.description.abstractThe effects of clopidogrel on mitochondrial respiratory function have not been previously investigated. We show in vitro that isolated mice liver mitochondria treated with very high doses of clopidogrel 10 μg/ml significantly reduces pre-treatment mitochondrial respiratory state 3 (P < 0.05) and state 4 respiration (P < 0.01), while oxygen consumption in State 3 is prolonged. This suggests a compromise to mitochondrial oxidative phosphorylation following the addition of high dose clopidogrel. Because clopidogrel at human therapeutic doses 40 ng/ml did not affect isolated mitochondrial respiration, it is thus unlikely, in the absence of cellular bioaccumulation, that clinical doses of clopidogrel would affect mitochondrial bioenergetics in vivo. © 2009.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ijcard.2007.10.022
dc.sourceScopus
dc.subjectBioenergetics
dc.subjectClopidogrel
dc.subjectLiver
dc.subjectMice
dc.subjectMitochondria
dc.subjectP2Y12
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.ijcard.2007.10.022
dc.description.sourcetitleInternational Journal of Cardiology
dc.description.volume133
dc.description.issue2
dc.description.page250-252
dc.description.codenIJCDD
dc.identifier.isiut000264284500020
dc.published.statePublished
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