Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.pain.2005.11.016
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dc.titleHippocampal theta state in relation to formalin nociception
dc.contributor.authorTai, S.K.
dc.contributor.authorHuang, F.-D.
dc.contributor.authorMoochhala, S.
dc.contributor.authorKhanna, S.
dc.date.accessioned2016-11-29T01:20:18Z
dc.date.available2016-11-29T01:20:18Z
dc.date.issued2006-03
dc.identifier.citationTai, S.K., Huang, F.-D., Moochhala, S., Khanna, S. (2006-03). Hippocampal theta state in relation to formalin nociception. Pain 121 (1-2) : 29-42. ScholarBank@NUS Repository. https://doi.org/10.1016/j.pain.2005.11.016
dc.identifier.issn03043959
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131579
dc.description.abstractIn the present study using extracellular electrophysiological recording techniques, we explored the temporal characteristics of hippocampal theta activation in relation to formalin nociception. Results indicate that, compared to hind paw injection of saline, formalin injection in behaving rat evoked biphasic increase in duration of dorsal CA1 theta. Such an increase broadly paralleled animal biphasic behavioral activation, especially lick and moment-to-moment agitated behaviors. Correspondingly, theta-modulated cell firing was observed following formalin injection in anesthetized rat. The formalin-induced theta activation in behaving rat was most marked during peak of theta activation in the 2nd theta state (11-40 min post-injection) comprising 73% of the time in the 5 min block. An increase in theta peak frequency was also observed with respect to pre-injection control. However, the peak of theta in the 2nd theta state mostly preceded the peak of lick and flinch of the affected paw. In the 41-60 min, following formalin injection while the animals displayed robust nociceptive flinching and lifting, the theta activity approached control levels. Furthermore, the theta peak frequency at peak of theta was higher than the corresponding values of sustained theta observed in correlation with the nociceptive behaviors; in contrast, high frequency theta rhythm was observed during formalin-induced other moment-to-moment agitated behaviors. These findings favor the notion that in the formalin model the theta state of the hippocampus reflects a neural drive that is dissociated from the duration of nociceptive experience and is not selective to the typical nociceptive indices of lick, flinch, and lift of the injured paw. © 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.pain.2005.11.016
dc.sourceScopus
dc.subjectBehaving rat
dc.subjectFormalin nociception
dc.subjectHippocampus field CA1
dc.subjectPyramidal cells
dc.subjectRhythmic discharge
dc.subjectTheta
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.pain.2005.11.016
dc.description.sourcetitlePain
dc.description.volume121
dc.description.issue1-2
dc.description.page29-42
dc.description.codenPAIND
dc.identifier.isiut000236076000005
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