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Title: Oxaliplatin/Fluorouracil/Leucovorin in Advanced Colorectal Carcinoma: An Asian Experience
Authors: Lim, E.H. 
Lim, R.S.C.
Wu, T.S.
Kong, H.L. 
Keywords: Asian
Colorectal carcinoma
Issue Date: Dec-2003
Citation: Lim, E.H., Lim, R.S.C., Wu, T.S., Kong, H.L. (2003-12). Oxaliplatin/Fluorouracil/Leucovorin in Advanced Colorectal Carcinoma: An Asian Experience. Annals of Pharmacotherapy 37 (12) : 1909-1912. ScholarBank@NUS Repository.
Abstract: BACKGROUND: Oxaliplatin/fluorouracil/leucovorin (FOLFOX4) is an effective and generally well-tolerated regimen in Western studies of metastatic colorectal carcinoma. OBJECTIVE: To evaluate the objective tumor responses and toxicities of the FOLFOX4 regimen in a predominantly Chinese population with advanced colorectal carcinoma in Singapore. METHODS: Forty-seven consecutive patients were enrolled in a retrospective study between March 1998 and December 2001. FOLFOX4 was first-line treatment in 36% of these patients, second-line in 36%, third-line in 17%, and fourth-line in 11%. Tumor responses were assessed radiologically, and toxicities were graded by the National Cancer Institute common toxicity system. RESULTS: The objective response rate (all partial responses) was 45%, and stable disease was achieved in 35% of the patients. There were no deaths due to toxicity. Mild to moderate peripheral sensory neuropathy affected half of the patients, with 1 report of cold exacerbation in this tropical series. The rate of hypersensitivity reactions to oxaliplatin was 11%, and they usually occurred late in the treatment course. CONCLUSIONS: FOLFOX4 has good efficacy in metastatic colorectal carcinoma in our local population, but the rate of hypersensitivity reactions to oxaliplatin was high.
Source Title: Annals of Pharmacotherapy
ISSN: 10600280
DOI: 10.1345/aph.1D153
Appears in Collections:Staff Publications

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