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Title: Gastroesophageal reflux disease is a common cause of noncardiac chest pain in a country with a low prevalence of reflux esophagitis
Authors: Ho, K.Y.
Ng, W.L. 
Kang, J.Y. 
Yeoh, K.G. 
Keywords: Esophageal motility disorder
Esophageal pH recording
Esophageal pressure recording
Gastroesophageal reflux disease
Noncardiac chest pain
Symptom analysis
Issue Date: 1998
Citation: Ho, K.Y., Ng, W.L., Kang, J.Y., Yeoh, K.G. (1998). Gastroesophageal reflux disease is a common cause of noncardiac chest pain in a country with a low prevalence of reflux esophagitis. Digestive Diseases and Sciences 43 (9) : 1991-1997. ScholarBank@NUS Repository.
Abstract: Gastroesophageal reflux disease is believed to be uncommon in the East. This study aimed to determine if such a condition was a significant cause of noncardiac chest pain in Singapore. Eighty consecutive patients with recurrent chest pain, who had cardiac and other obvious causes excluded, underwent esophagogastroduodenoscopy, standard manometry, acid perfusion test, and prolonged ambulatory pH and pressure monitoring. Endoscopic esophagitis, positive acid perfusion tests, pathologic reflux, and positive chest pain-reflux correlation were detected in 7/80 (8.8%), 11/70 (15.7%), 14/61 (23.0%), and 12/25 (48.0%) patients, respectively. Among those with pathologic reflux, endoscopic esophagitis was present in only two (14.3%). Overall, 32 (40%) patients had gastroesophageal reflux disease. Esophageal motility disorder, alone or in association with gastroesophageal reflux disease, was demonstrated in only five (6.3%) patients. Our results confirmed western reports that gastroesophageal reflux disease was a common cause of noncardiac chest pain, whereas motility disorder was an infrequent cause of such pain.
Source Title: Digestive Diseases and Sciences
ISSN: 01632116
DOI: 10.1023/A:1018842811123
Appears in Collections:Staff Publications

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