Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131184
DC FieldValue
dc.titleHepatocyte hepatitis B surface antigen expression in chronic hepatitis B virus carriers in Singapore: Correlation with viral replication and liver pathology
dc.contributor.authorWee, A.
dc.contributor.authorYap, I.
dc.contributor.authorGuan, R.
dc.date.accessioned2016-11-28T10:17:12Z
dc.date.available2016-11-28T10:17:12Z
dc.date.issued1991
dc.identifier.citationWee, A., Yap, I., Guan, R. (1991). Hepatocyte hepatitis B surface antigen expression in chronic hepatitis B virus carriers in Singapore: Correlation with viral replication and liver pathology. Journal of Gastroenterology and Hepatology 6 (5) : 466-470. ScholarBank@NUS Repository.
dc.identifier.issn08159319
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131184
dc.description.abstractThe hepatocyte hepatitis B surface antigen (HBsAg) expression in 149 liver biopsies from 124 chronic hepatitis B virus (HBV) carriers was correlated with serum HBV DNA status and histologic activity. Hepatocyte HBsAg was stained by the peroxidase-antiperoxidase method and serum HBV DNA was determined by dot blot hybridization. Sixty-five biopsies (44%) showed minimal changes (MC), 82 biopsies (55%) showed chronic liver disease (CLD) and 2 biopsies (1%) showed hepatocellular carcinoma. Hepatocyte HBsAg was found in 144 biopsies (97%). It was present in the cytoplasm of 141 specimens (95%) and/or plasma membrane of 48 specimens (32%). Approximately half (45%) of the cytoplasmic HBsAg-positive biopsies showed discrete distribution, while the other half (55%) were grouped. Fifty-five per cent (77 of 141) of cytoplasmic HBsAg-positive biopsies had CLD, while 44% (62 of 141) showed MC. There was no relationship between the presence of cytoplasmic HBsAg or its topographic distribution with disease activity. Membrane HBsAg distribution was similar for both groups of patients (MC vs CLD: 25 of 65 (38%) vs 23 of 82 (28%); P = NS). Serum HBV DNA was detected in 98 patients (66%) and was seen mostly in association with CLD (CLD vs MC: 61% vs 39%, P < 0.001). It was also detected more often in the sera of patients with membrane HBsAg than in those with cytoplasmic HBsAg staining (41 of 48 (85%) vs 97 of 141 (67%); P < 0.02). However, discrete distribution of cytoplasmic HBsAg was associated with positive serum HBV DNA when compared with grouped distribution (52 of 63 (83%) vs 43 of 78 vs (55%); P < 0.005).
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.sourcetitleJournal of Gastroenterology and Hepatology
dc.description.volume6
dc.description.issue5
dc.description.page466-470
dc.description.codenJGHEE
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.