Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0306-4522(99)00119-0
DC FieldValue
dc.titleHippocampal field CA1 interneuronal nociceptive responses: Modulation by medial septal region and morphine
dc.contributor.authorZheng, F.
dc.contributor.authorKhanna, S.
dc.date.accessioned2016-11-28T10:16:29Z
dc.date.available2016-11-28T10:16:29Z
dc.date.issued1999-06
dc.identifier.citationZheng, F., Khanna, S. (1999-06). Hippocampal field CA1 interneuronal nociceptive responses: Modulation by medial septal region and morphine. Neuroscience 93 (1) : 45-55. ScholarBank@NUS Repository. https://doi.org/10.1016/S0306-4522(99)00119-0
dc.identifier.issn03064522
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131121
dc.description.abstractA majority (24/32) of the extracellularly recorded dorsal hippocampus field CA1 putative GABAergic interneurons were excited in conjunction with theta activation on formalin injection (5%, 0.05 ml, s.c. into right hind- paw) in urethane (1.0 g/kg, i.p.)-anaesthetized rats. An increase in activity was observed to the 10th minute (n=24) and also at later time-periods at which a few of the neurons were recorded following injection of formalin. The mean peak increase in activity within 5 min of formalin injection was 6.43±0.81 Hz over the average background activity for these neurons (6.46±1.04 Hz). Of 24 neurons, 14 exhibited an increase in activity which was rhythmically modulated with theta. With a concurrent administration of formalin and morphine (5 mg/kg, i.p.), the presumed interneurons recorded displayed an initial increase in discharge rate (mean peak increase within 5 min of 6.95±1.10 Hz) which then declined with a decrease in theta activity. The effect of concurrent morphine was naloxone reversible. Morphine administration alone resulted in an immediate decrease in the interneuronal firing rate. In presence of the medial septal region lesions, formalin did not evoke an excitation of interneurons or theta activation. Further, such lesions prevented the decrease in interneuron activity to morphine administration. The above data are consistent with the notion that (i) the field CA1 interneurons participate in a noxious stimulus-induced and medial septal region mediated pyramidal cell suppression, and (ii) morphine affects CA1 nociceptive responses partly in a fashion consistent with the effect of the drug on septohippocampal neural network processing.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0306-4522(99)00119-0
dc.sourceScopus
dc.subjectDorsal hippocampus
dc.subjectFormalin nociception
dc.subjectGABAergic interneuronal excitation
dc.subjectMedial septal region
dc.subjectMorphine
dc.subjectRhythmic theta modulation
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/S0306-4522(99)00119-0
dc.description.sourcetitleNeuroscience
dc.description.volume93
dc.description.issue1
dc.description.page45-55
dc.description.codenNRSCD
dc.identifier.isiut000081196200004
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

22
checked on Aug 5, 2020

WEB OF SCIENCETM
Citations

19
checked on Jul 28, 2020

Page view(s)

48
checked on Jul 31, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.