Please use this identifier to cite or link to this item: https://doi.org/10.1038/modpathol.3800125
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dc.titleIncreased c-kit (CD117) expression in malignant mammary phyllodes tumors
dc.contributor.authorTse, G.M.K.
dc.contributor.authorPutti, T.C.
dc.contributor.authorLui, P.C.W.
dc.contributor.authorLo, A.W.I.
dc.contributor.authorScolyer, R.A.
dc.contributor.authorLaw, B.K.B.
dc.contributor.authorKarim, R.
dc.contributor.authorLee, C.S.
dc.date.accessioned2016-11-28T10:16:21Z
dc.date.available2016-11-28T10:16:21Z
dc.date.issued2004-07
dc.identifier.citationTse, G.M.K., Putti, T.C., Lui, P.C.W., Lo, A.W.I., Scolyer, R.A., Law, B.K.B., Karim, R., Lee, C.S. (2004-07). Increased c-kit (CD117) expression in malignant mammary phyllodes tumors. Modern Pathology 17 (7) : 827-831. ScholarBank@NUS Repository. https://doi.org/10.1038/modpathol.3800125
dc.identifier.issn08933952
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131109
dc.description.abstractMammary phyllodes tumors are uncommon stromal neoplasms, and are divided into benign, borderline and malignant groups basing on histologic criteria. While benign phyllodes tumors may recur, borderline phyllodes tumors show higher propensity to recur locally and rarely metastasize, and malignant phyllodes tumors show even higher chances of local recurrences or distant metastases. c-kit is a proto-oncogene that encodes a tyrosine kinase receptor (CD117) and is a marker for gastrointestinal stromal tumors (GIST). With the advent of therapeutic agent targeted at this receptor for GIST, we investigated 179 phyllodes tumors (101 benign, 50 borderline, 28 malignant) for c-kit expression using immunohistochemistry. The staining was compared to the degree of malignancy, and to the degree of stromal cellularity, mitotic activity, nuclear pleomorphism and stromal overgrowth. The overall positive rate for c-kit was 29% (52/178) and 17% (17/101), 24% (12/50) and 46% (13/28), respectively, for benign, borderline malignant and frank malignant phyllodes and the differences between all categories were significant (χ2 = 13.844, P=0.001). In mammary phyllodes tumors, there was increasing c-kit expression with increasing degree of malignancy, up to 46% in malignant cases. This provides strong evidence that c-kit receptor mediated tyrosine kinase involvement in the pathogenesis of phyllodes tumors, and the therapeutic agent, STI571, Glivec, may be a potentially useful drug for its management.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/modpathol.3800125
dc.sourceScopus
dc.subjectBreast
dc.subjectc-kit
dc.subjectCD117
dc.subjectImmunohistochemistry
dc.subjectPhyllodes tumor
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.description.doi10.1038/modpathol.3800125
dc.description.sourcetitleModern Pathology
dc.description.volume17
dc.description.issue7
dc.description.page827-831
dc.description.codenMODPE
dc.identifier.isiut000223118200011
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