Please use this identifier to cite or link to this item: https://doi.org/10.1002/path.1899
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dc.titleThe effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis
dc.contributor.authorLau, H.Y.
dc.contributor.authorBhatia, M.
dc.date.accessioned2016-11-17T08:39:08Z
dc.date.available2016-11-17T08:39:08Z
dc.date.issued2006-02
dc.identifier.citationLau, H.Y., Bhatia, M. (2006-02). The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Journal of Pathology 208 (3) : 364-371. ScholarBank@NUS Repository. https://doi.org/10.1002/path.1899
dc.identifier.issn00223417
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130605
dc.description.abstractAcute pancreatitis (AP) is a life-threatening condition that involves an acute inflammatory process in the pancreas. The involvement of tachykinins and neurokinin receptors in acute pancreatitis has been described only recently, despite their long-established role in inflammatory conditions. Among these, substance P (SP) is believed to play a central role in exacerbating the inflammatory process by acting through neurokinin-1 receptor (NK1R). Treatment with the NK1R antagonist, CP96,345, results in protection against caerulein-induced acute pancreatitis in mice. However, the mechanism by which NK1R and SP worsen the condition is still unclear. In the present study, we have investigated the effect of NK1R blockage on the expression of preprotachykinin genes and neurokinin receptors in acute pancreatitis. In the pancreas, CP96,345 treatment resulted in suppression of the elevation of SP concentration, preprotachykinin-A gene (PPT-A) mRNA expression, and NK1R mRNA and protein expression. In the lungs, the antagonist was found to suppress the increase in SP concentration, PPT-A mRNA expression and preprotachykinin-C gene (PPT-C) mRNA expression. However, the antagonist treatment further promoted the accumulation of pulmonary NK1R mRNA and protein expression. Neurokinin-2 receptor (NK2R) mRNA expression was not detected in normal pancreas. However, up-regulated expression of the mRNA for this receptor was observed during acute pancreatitis and treatment with CP96,345 further increased this expression. Pulmonary NK2R mRNA expression was found to be reduced during acute pancreatitis and CP96,345 treatment normalized this reduction. Neurokinin-3 receptor (NK3R) mRNA expression was absent in both pancreas and lung. These data have provided valuable information regarding the regulation of tachykinins and neurokinin receptors during acute pancreatitis. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/path.1899
dc.sourceScopus
dc.subjectAcute pancreatitis
dc.subjectCP96,345
dc.subjectLung
dc.subjectNeurokinin receptors
dc.subjectPancreas
dc.subjectTachykinins
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1002/path.1899
dc.description.sourcetitleJournal of Pathology
dc.description.volume208
dc.description.issue3
dc.description.page364-371
dc.description.codenJPTLA
dc.identifier.isiut000235374500006
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