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|Title:||Sirolimus-eluting, bioabsorbable polymer-coated constant stent (Cura®) in acute ST-elevation myocardial infarction: A clinical and angiographic study (CURAMI registry)||Authors:||Lee, C.-H.
|Issue Date:||Apr-2007||Citation:||Lee, C.-H., Lim, J., Low, A., Zhang, X.-L., Kyaing, T.-T., Chan, M.Y., Wong, H.-B., Lim, Y.-T., Tan, H.-C. (2007-04). Sirolimus-eluting, bioabsorbable polymer-coated constant stent (Cura®) in acute ST-elevation myocardial infarction: A clinical and angiographic study (CURAMI registry). Journal of Invasive Cardiology 19 (4) : 182-185. ScholarBank@NUS Repository.||Abstract:||BACKGROUND: There are safety concerns over the current polymer-based drug-eluting stents (DES) on the possible delayed healing process and adverse reactions to the polymer when drug elution is completed. Cura® (Orbus Neich) is a sirolimus-eluting, bioabsorbable, polymer-coated constant stent. METHODS: From March 1 to June 30, 2005, Cura stent implantation was instituted as the default strategy for percutaneous coronary intervention in 49 consecutive ST-Elevation Myocardial Infarction (STEMI) patients (male 86%; average age 55 ± 10 years; diabetes 31%). RESULTS: The angiographic success rate was 100%. In-hospital adverse events consisted of 1 in-hospital death (2% heart failure). A total of 27 patients (56%) underwent 8-month angiographic follow up. Binary restenosis occurred in 6 patients (22%), and late loss was 0.74 ± 0.89 mm. At 9-month follow up, a total of 5 patients had 6 major adverse events (1 death, 1 reinfarction, and 4 target lesion revascularizations). There was no incidence of stent thrombosis. CONCLUSION: Cura stent implantation appears to be feasible and safe in the treatment of STEMI. However, the binary restenosis rate and late loss at angiographic follow up were similar to that of bare-metal stents, and therefore compare unfavorably with other proven benchmark DES. © 2007 HMP Communications | All Rights Reserved.||Source Title:||Journal of Invasive Cardiology||URI:||http://scholarbank.nus.edu.sg/handle/10635/130570||ISSN:||10423931|
|Appears in Collections:||Staff Publications|
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