Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/130395
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dc.titleThe CCK2 agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat
dc.contributor.authorFarook, J.M.
dc.contributor.authorMcLachlan, C.S.
dc.contributor.authorZhu, Y.Z.
dc.contributor.authorLee, L.
dc.contributor.authorMoochhala, S.M.
dc.contributor.authorWong, P.T.-H.
dc.date.accessioned2016-11-16T11:05:29Z
dc.date.available2016-11-16T11:05:29Z
dc.date.issued2004-01-30
dc.identifier.citationFarook, J.M., McLachlan, C.S., Zhu, Y.Z., Lee, L., Moochhala, S.M., Wong, P.T.-H. (2004-01-30). The CCK2 agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat. Neuroscience Letters 355 (3) : 205-208. ScholarBank@NUS Repository.
dc.identifier.issn03043940
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130395
dc.description.abstractOur previous studies (NeuroReport 12 (2001) 2717) showed that PVG hooded and not Sprague-Dawley (SD) rats exhibit remarkable freezing behavior on exposure to a cat in the cat freezing test apparatus. In the present study, we further examined the differences between these two strains of rats in response to repeated daily exposure to a cat in the cat freezing test apparatus. Freezing behavior habituation was observed in both PVG hooded (days 5-7) and SD rats (days 3-7). A selective CCK2 agonist (BC264, 0.3 μg/kg, i.p.) on day 8 reversed habituated freezing behavior and locomotor activity in PVG hooded rats, but not in SD rats. These results suggest that CCK2 receptors mediate habituation to an anxiety-inducing stimulus in PVG hooded rats and further suggest that differential expression of these CCK2 receptors underlies this strain difference. © 2003 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neulet.2003.11.010
dc.sourceScopus
dc.subjectBehavior
dc.subjectFreezing
dc.subjectHabituation
dc.subjectPVG hooded and Sprague-Dawley
dc.subjectRats
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.sourcetitleNeuroscience Letters
dc.description.volume355
dc.description.issue3
dc.description.page205-208
dc.description.codenNELED
dc.identifier.isiut000188396500013
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