Please use this identifier to cite or link to this item: https://doi.org/10.2174/138945008784911796
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dc.titleWnt signaling in development, disease and translational medicine
dc.contributor.authorCoombs, G.S.
dc.contributor.authorCovey, T.M.
dc.contributor.authorVirshup, D.M.
dc.date.accessioned2016-11-11T08:01:31Z
dc.date.available2016-11-11T08:01:31Z
dc.date.issued2008
dc.identifier.citationCoombs, G.S., Covey, T.M., Virshup, D.M. (2008). Wnt signaling in development, disease and translational medicine. Current Drug Targets 9 (7) : 513-531. ScholarBank@NUS Repository. https://doi.org/10.2174/138945008784911796
dc.identifier.issn13894501
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130154
dc.description.abstractWnt signaling regulates a multitude of critical processes in development and tissue homeostasis. The wingless (wg) gene product was first identified in Drosophila in 1973. Subsequently, the proto-oncogene INT-1 was identified in mice in 1984 when its activation by mouse mammary tumor virus' proviral insertion was found to induce tumor formation. The discovery in 1987 that wg and INT-1 are orthologues contributed to an appreciation of the intimate connection between oncogenic and developmental processes. Diverse diseases including cancer, diabetes, osteoporosis and psychiatric disorders may be amenable to treatment via modulation of Wnt-mediated signaling pathways. There are a number of attractive targets that are the object of ongoing drug development studies aiming to capitalize on these opportunities. In this review, we present a historical overview of key events in this field that have elucidated the known signaling cascades associated with Wnt ligands and shaped our understanding of the roles of these cascades in physiological and pathological processes. © 2008 Bentham Science Publishers Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2174/138945008784911796
dc.sourceScopus
dc.typeReview
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.2174/138945008784911796
dc.description.sourcetitleCurrent Drug Targets
dc.description.volume9
dc.description.issue7
dc.description.page513-531
dc.description.codenCDTUA
dc.identifier.isiut000257455900002
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