Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pgen.1000176
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dc.titleSomatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated ELGN2-mediated oxygen-sensing response
dc.contributor.authorKoeman, J.M.
dc.contributor.authorRussell, R.C.
dc.contributor.authorTan, M.-H.
dc.contributor.authorPetillo, D.
dc.contributor.authorWestphal, M.
dc.contributor.authorKoelzer, K.
dc.contributor.authorMetcalf, J.L.
dc.contributor.authorZhang, Z.
dc.contributor.authorMatsuda, D.
dc.contributor.authorDykema, K.J.
dc.contributor.authorHouseman, H.L.
dc.contributor.authorKort, E.J.
dc.contributor.authorFurge, L.L.
dc.contributor.authorKahnoski, R.J.
dc.contributor.authorRichard, S.
dc.contributor.authorVieillefond, A.
dc.contributor.authorSwiatek, P.J.
dc.contributor.authorTeh, B.T.
dc.contributor.authorOhh, M.
dc.contributor.authorFurge, K.A.
dc.date.accessioned2016-11-11T08:00:00Z
dc.date.available2016-11-11T08:00:00Z
dc.date.issued2008-09
dc.identifier.citationKoeman, J.M., Russell, R.C., Tan, M.-H., Petillo, D., Westphal, M., Koelzer, K., Metcalf, J.L., Zhang, Z., Matsuda, D., Dykema, K.J., Houseman, H.L., Kort, E.J., Furge, L.L., Kahnoski, R.J., Richard, S., Vieillefond, A., Swiatek, P.J., Teh, B.T., Ohh, M., Furge, K.A. (2008-09). Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated ELGN2-mediated oxygen-sensing response. PLoS Genetics 4 (9) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1000176
dc.identifier.issn15537390
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130018
dc.description.abstractChromosomal abnormalities, such as structural and numerical abnormalities, are a common occurrence in cancer. The close association of homologous chromosomes during interphase, a phenomenon termed somatic chromosome pairing, has been observed in cancerous cells, but the functional consequences of somatic pairing have not been established. Gene expression profiling studies revealed that somatic pairing of chromosome 19 is a recurrent chromosomal abnormality in renal oncocytoma, a neoplasia of the adult kidney. Somatic pairing was associated with significant disruption of gene expression within the paired regions and resulted in the deregulation of the prolyl-hydroxylase ELGN2, a key protein that regulates the oxygen-dependent degradation of hypoxia-inducible factor (HIF). Overexpression of ELGN2 in renal oncocytoma increased ubiquitin-mediated destruction of HIF and concomitantly suppressed the expression of several HIF-target genes, including the pro-death BNIP3L gene. The transcriptional changes that are associated with somatic pairing of chromosome 19 mimic the transcriptional changes that occur following DNA amplification. Therefore, in addition to numerical and structural chromosomal abnormalities, alterations in chromosomal spatial dynamics should be considered as genomic events that are associated with tumorigenesis. The identification of EGLN2 as a significantly deregulated gene that maps within the paired chromosome region directly implicates defects in the oxygen-sensing network to the biology of renal oncocytoma. © 2008 Koeman et al.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pgen.1000176
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1371/journal.pgen.1000176
dc.description.sourcetitlePLoS Genetics
dc.description.volume4
dc.description.issue9
dc.description.page-
dc.identifier.isiut000260411200027
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