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Title: B-type natriuretic peptide: Issues for the intensivist and pulmonologist
Authors: Jason, P.
Keang, L.T. 
Hoe, L.K. 
Keywords: B-type natriuretic peptide
Critical illness
Heart failure
N-terminal pro-B-type natriuretic peptide
Pulmonary diseases
Issue Date: Sep-2005
Citation: Jason, P., Keang, L.T., Hoe, L.K. (2005-09). B-type natriuretic peptide: Issues for the intensivist and pulmonologist. Critical Care Medicine 33 (9) : 2094-2103. ScholarBank@NUS Repository.
Abstract: Objective: B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP), although promising as biomarkers for heart failure, are affected by multiple confounders. The purpose of this article is to review the literature on the utility of BNP and NT-proBNP as biomarkers, with a focus on their role in critical illness and pulmonary diseases. Data Source: Published articles on BNP and NT-proBNP. Data Analysis: Multiple disorders in the intensive care unit cause elevated BNP and NT-proBNP levels, including cardiac diseases, shock, pulmonary hypertension, acute respiratory distress syndrome, acute pulmonary embolism, chronic obstructive pulmonary disease, renal failure, and other conditions. Conclusions: Intensivists and pulmonologists should understand that BNP and NT-proBNP levels might be raised to different degrees not only in heart failure but also in critical illness and various pulmonary diseases; in these situations, BNP and NT-proBNP may also serve as markers of severity and prognosis. Copyright © 2005 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins.
Source Title: Critical Care Medicine
ISSN: 00903493
DOI: 10.1097/01.CCM.0000178351.03327.9F
Appears in Collections:Staff Publications

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