Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1478-3231.2007.01461.x
Title: Drug-induced liver injury at an Asian center: A prospective study
Authors: Wai, C.-T. 
Tan, B.-H.
Chan, C.-L.
Sutedja, D.S.
Lee, Y.-M. 
Khor, C.
Lim, S.-G. 
Keywords: Asia
DILI
Hepatitis
Herbs
Issue Date: May-2007
Citation: Wai, C.-T., Tan, B.-H., Chan, C.-L., Sutedja, D.S., Lee, Y.-M., Khor, C., Lim, S.-G. (2007-05). Drug-induced liver injury at an Asian center: A prospective study. Liver International 27 (4) : 465-474. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1478-3231.2007.01461.x
Abstract: Background/Aims: The aetiology of drug-induced liver injuries (DILI) in Asia is different from that in the West, as anecdotal studies have shown that traditional complementary and alternative medicines (CAM) accounted for a major proportion of offending drugs in DILI in Asia. We aimed to study DILI in Asia prospectively, and to test whether DILI caused by traditional CAM was related to adulterants. Methods: A collaborative group consisting of a tertiary-hospital hepatology department, a pharmaceutical laboratory, and a pharmacovigilance unit was formed to study patients with DILI at a tertiary hospital over a 26-month period prospectively. Traditional medicines that were implicated were tested for the presence of adulterants. Results: Thirty-one patients with DILI were enrolled: age 51 ± 3 (18-79) years, 17 (55%) male. Twenty-three (74%) had hepatocellular, six (19%) had cholestatic, and two (7%) had a mixed pattern of injury. Chinese traditional CAM was the most common medication type implicated, accounting for 17 (55%) patients, followed by Malay CAM in five (16%). Thirty-one traditional medicines from 17 patients were available for chemical analysis. Adulterants were found in nine (29%) of them. Conclusions: DILI in Asia has a different aetiology as compared with the West, and could be related to presence of adulterants in traditional CAM. © 2007 Blackwell Munksgaard.
Source Title: Liver International
URI: http://scholarbank.nus.edu.sg/handle/10635/129772
ISSN: 14783223
DOI: 10.1111/j.1478-3231.2007.01461.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

77
checked on Jul 13, 2019

WEB OF SCIENCETM
Citations

72
checked on Jun 28, 2019

Page view(s)

45
checked on Jul 12, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.