Please use this identifier to cite or link to this item:
Title: Acute lymphoblastic leukemia with the phenotype of a putative B-cell/T-cell bipotential precursor
Authors: Lau, L.G.
Tan, L.K. 
Koay, E.S.C. 
Ee, M.H.L.
Tan, S.H.
Liu, T.C. 
Keywords: Acute lymphoblastic leukemia
Lymphoid progenitor cell
Issue Date: Oct-2004
Citation: Lau, L.G., Tan, L.K., Koay, E.S.C., Ee, M.H.L., Tan, S.H., Liu, T.C. (2004-10). Acute lymphoblastic leukemia with the phenotype of a putative B-cell/T-cell bipotential precursor. American Journal of Hematology 77 (2) : 156-160. ScholarBank@NUS Repository.
Abstract: Biphenotypic acute leukemias (BALs) are uncommon. Most are of myeloid-B-cell or myeloid-T-cell lineage. We report herein a 70-year-old man with an unusual acute leukemia where the blasts expressed both B- and T-lymphoid markers. He presented to us with an enlarging cutaneous tumor. The presenting peripheral blood and bone marrow aspirate showed 40% and 90% blasts, respectively, which were negative for the usual cytochemical stains. The flow cytometric analysis revealed that the blasts were positive for CD19, CD20, CD22, cytoplasmic (Cyt) CD79a, CD10, Cyt CD3, CD5, CD7, CD4, HLA-DR, TdT, and were negative for myeloid markers. According to the scoring system from the European Group for the Immunological Characterization of Acute Leukaemias (EGIL), this case was an unequivocal B-cell/T-cell BAL. Conventional cytogenetic analysis revealed 46XY [t(4;11)(q31;q13), add(8)(q24), der(9)del(9)(p21)del(9)(q32q34), -13, +mar] in all 25 metaphases analyzed. Fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) for 11q23 rearrangements as well as t(9;22) were negative. PCR for both TCR-γ and IgH gene analyses revealed polyclonal rearrangements. We postulate that this case of BAL might have arisen from the putative common lymphoid progenitor cell. © 2004 Wiley-Liss, Inc.
Source Title: American Journal of Hematology
ISSN: 03618609
DOI: 10.1002/ajh.20163
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Sep 29, 2022


checked on Sep 29, 2022

Page view(s)

checked on Sep 22, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.