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Title: Additive effect of unoprostone and latanoprost in patients with elevated intraocular pressure
Authors: Aung, T. 
Chew, P.T.K. 
Oen, F.T.S.
Chan, Y.-H.
Thean, L.H.
Yip, L.
Lim, B.-A.
Seah, S.K.L.
Issue Date: 2002
Citation: Aung, T., Chew, P.T.K., Oen, F.T.S., Chan, Y.-H., Thean, L.H., Yip, L., Lim, B.-A., Seah, S.K.L. (2002). Additive effect of unoprostone and latanoprost in patients with elevated intraocular pressure. British Journal of Ophthalmology 86 (1) : 75-79. ScholarBank@NUS Repository.
Abstract: Aims: To assess the additive effect of unoprostone and latanoprost in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT). Methods: 32 patients with POAG or OHT were randomised to receive either latanoprost once daily or unoprostone twice daily for 4 weeks. After 4 weeks, all patients received both latanoprost and unoprostone for another 4 weeks. The IOP was measured at 9 am and 5 pm on the baseline, day 28, and day 56 visits, and at 9 am on day 14 and day 42 visits. The medications were given to the patients in an open label fashion. The observer was masked to the treatment given. The meon of the measurements was calculated. Safety parameters were also recorded. The additive effect of the medications was assessed by the reduction in intraocular pressure (IOP) when both medications were used, compared with when one medication was used. Results: 28 patients completed both treatment periods and had IOP data available for evaluation. After 1 month of treatment, latanoprost significantly reduced IOP (mean by 6.1 (SEM 0.8)mm Hg (p
Source Title: British Journal of Ophthalmology
ISSN: 00071161
DOI: 10.1136/bjo.86.1.75
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