Please use this identifier to cite or link to this item: https://doi.org/10.1097/MCC.0b013e32834e7d00
Title: Ventilator-induced lung injury: The role of gene activation
Authors: Ngiam, N. 
Kavanagh, B.P.
Keywords: gene expression
mechanical ventilation
signaling pathways
ventilator-induced lung injury
Issue Date: Feb-2012
Citation: Ngiam, N., Kavanagh, B.P. (2012-02). Ventilator-induced lung injury: The role of gene activation. Current Opinion in Critical Care 18 (1) : 16-22. ScholarBank@NUS Repository. https://doi.org/10.1097/MCC.0b013e32834e7d00
Abstract: Purpose of Review: Ventilator-induced lung injury (VILI) is a ubiquitous iatrogenic clinical problem in critical care. Aside from avoiding large tidal volumes, little progress has been made in identifying effective clinical strategies to minimize this injury. With recent rapid development in bioinformatics and high-throughput molecular technology, the genetic basis of lung injury has been intensively investigated. This review will describe recent insights and potential therapies developed in the field. Recent Findings: Much progress has been made in delineating the possible genes and gene products involved in VILI through various mechanisms such as early induced genes, capillary leak, apoptosis, fibrin deposition, inflammatory cytokines, oxidative stress, disrupted angiogenesis, and neutrophil infiltration. Some studies have translated bench findings to the bedside in an attempt to identify clinically important genetic susceptibility, which could aid in the identification of at-risk individuals who might benefit from careful titration of mechanical ventilation. Genetic insights also provide candidate pharmaceutical approaches that may ameliorate VILI in the future. Summary: Much relevant information exists for investigators and clinicians interested in VILI. Future research will interlink evolving data to provide a more integrated picture of the molecular mechanisms involved in VILI enabling translation of the most promising candidate therapies. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Source Title: Current Opinion in Critical Care
URI: http://scholarbank.nus.edu.sg/handle/10635/128978
ISSN: 10705295
DOI: 10.1097/MCC.0b013e32834e7d00
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

17
checked on Aug 12, 2020

WEB OF SCIENCETM
Citations

14
checked on Aug 3, 2020

Page view(s)

59
checked on Jul 31, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.