Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ophtha.2013.10.023
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dc.titleRADIANCE: A randomized controlled study of ranibizumab in patients with choroidal neovascularization secondary to pathologic myopia
dc.contributor.authorWolf, S.
dc.contributor.authorBalciuniene, V.J.
dc.contributor.authorLaganovska, G.
dc.contributor.authorMenchini, U.
dc.contributor.authorOhno-Matsui, K.
dc.contributor.authorSharma, T.
dc.contributor.authorWong, T.Y.
dc.contributor.authorSilva, R.
dc.contributor.authorPilz, S.
dc.contributor.authorGekkieva, M.
dc.date.accessioned2016-10-19T08:43:31Z
dc.date.available2016-10-19T08:43:31Z
dc.date.issued2014-03
dc.identifier.citationWolf, S., Balciuniene, V.J., Laganovska, G., Menchini, U., Ohno-Matsui, K., Sharma, T., Wong, T.Y., Silva, R., Pilz, S., Gekkieva, M. (2014-03). RADIANCE: A randomized controlled study of ranibizumab in patients with choroidal neovascularization secondary to pathologic myopia. Ophthalmology 121 (3) : 682-692. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ophtha.2013.10.023
dc.identifier.issn01616420
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/128642
dc.description.abstractObjective To compare the efficacy and safety of ranibizumab 0.5 mg, guided by visual acuity (VA) stabilization or disease activity criteria, versus verteporfin photodynamic therapy (vPDT) in patients with visual impairment due to myopic choroidal neovascularization (CNV). Design Phase III, 12-month, randomized, double-masked, multicenter, active-controlled study. Participants Patients (N = 277) with visual impairment due to myopic CNV. Methods Patients were randomized to receive ranibizumab on day 1, month 1, and thereafter as needed guided by VA stabilization criteria (group I, n = 106); ranibizumab on day 1 and thereafter as needed guided by disease activity criteria (group II, n = 116); or vPDT on day 1 and disease activity treated with ranibizumab or vPDT at investigators' discretion from month 3 (group III, n = 55). Main Outcome Measures Mean average best-corrected visual acuity (BCVA) change from baseline to month 1 through months 3 (primary) and 6, mean BCVA change and safety over 12 months. Results Ranibizumab treatment in groups I and II was superior to vPDT based on mean average BCVA change from baseline to month 1 through month 3 (group I: +10.5, group II: +10.6 vs. group III: +2.2 Early Treatment Diabetic Retinopathy Study [ETDRS] letters; both P < 0.0001). Ranibizumab treatment guided by disease activity was noninferior to VA stabilization-guided retreatment based on mean average BCVA change from baseline to month 1 through month 6 (group II: +11.7 vs. group I: +11.9 ETDRS letters; P < 0.00001). Mean BCVA change from baseline to month 12 was +13.8 (group I), +14.4 (group II), and +9.3 ETDRS letters (group III). At month 12, 63.8% to 65.7% of patients showed resolution of myopic CNV leakage. Patients received a median of 4.0 (group I) and 2.0 (groups II and III) ranibizumab injections over 12 months. No deaths or cases of endophthalmitis and myocardial infarction occurred. Conclusions Ranibizumab treatment, irrespective of retreatment criteria, provided superior BCVA gains versus vPDT up to month 3. Ranibizumab treatment guided by disease activity criteria was noninferior to VA stabilization criteria up to month 6. Over 12 months, individualized ranibizumab treatment was effective in improving and sustaining BCVA and was generally well tolerated in patients with myopic CNV. © 2014 by the American Academy of Ophthalmology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ophtha.2013.10.023
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.ophtha.2013.10.023
dc.description.sourcetitleOphthalmology
dc.description.volume121
dc.description.issue3
dc.description.page682-692
dc.description.codenOPHTD
dc.identifier.isiut000332401800018
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