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Title: Increased renal dopamine and acute renal adaptation to a high-phosphate diet
Authors: Weinman, E.J.
Biswas, R.
Steplock, D.
Wang, P.
Lau, Y.-S.
Desir, G.V.
Shenolikar, S. 
Keywords: Dopamine metabolism
Renal phosphate transport
Issue Date: May-2011
Citation: Weinman, E.J., Biswas, R., Steplock, D., Wang, P., Lau, Y.-S., Desir, G.V., Shenolikar, S. (2011-05). Increased renal dopamine and acute renal adaptation to a high-phosphate diet. American Journal of Physiology - Renal Physiology 300 (5) : 1123-1129. ScholarBank@NUS Repository.
Abstract: The current experiments explore the role of dopamine in facilitating the acute increase in renal phosphate excretion in response to a high-phosphate diet. Compared with a low-phosphate (0.1%) diet for 24 h, mice fed a high-phosphate (1.2%) diet had significantly higher rates of phosphate excretion in the urine associated with a two- to threefold increase in the dopamine content of the kidney and in the urinary excretion of dopamine. Animals fed a high-phosphate diet had a significant increase in the abundance and activity of renal DOPA (L-dihydroxyphenylalanine) decarboxylase and significant reductions in renalase, monoamine oxidase A, and monoamine oxidase B. The activity of protein kinase A and protein kinase C, markers of activation of renal dopamine receptors, were significantly higher in animals fed a high-phosphate vs. a lowphosphate diet. Treatment of rats with carbidopa, an inhibitor of DOPA decarboxylase, impaired adaptation to a high-phosphate diet. These experiments indicate that the rapid adaptation to a highphosphate diet involves alterations in key enzymes involved in dopamine synthesis and degradation, resulting in increased renal dopamine content and activation of the signaling cascade used by dopamine to inhibit the renal tubular reabsorption of phosphate. © 2011 by the American Physiological Society.
Source Title: American Journal of Physiology - Renal Physiology
ISSN: 03636127
DOI: 10.1152/ajprenal.00744.2010
Appears in Collections:Staff Publications

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