Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.2711
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dc.titleGenetic relationship between five psychiatric disorders estimated from genome-wide SNPs
dc.contributor.authorLee, S.H.
dc.contributor.authorRipke, S.
dc.contributor.authorNeale, B.M.
dc.contributor.authorFaraone, S.V.
dc.contributor.authorPurcell, S.M.
dc.contributor.authorPerlis, R.H.
dc.contributor.authorMowry, B.J.
dc.contributor.authorThapar, A.
dc.contributor.authorGoddard, M.E.
dc.contributor.authorWitte, J.S.
dc.contributor.authorAbsher, D.
dc.contributor.authorAgartz, I.
dc.contributor.authorAkil, H.
dc.contributor.authorAmin, F.
dc.contributor.authorAndreassen, O.A.
dc.contributor.authorAnjorin, A.
dc.contributor.authorAnney, R.
dc.contributor.authorAnttila, V.
dc.contributor.authorArking, D.E.
dc.contributor.authorAsherson, P.
dc.contributor.authorAzevedo, M.H.
dc.contributor.authorBacklund, L.
dc.contributor.authorBadner, J.A.
dc.contributor.authorBailey, A.J.
dc.contributor.authorBanaschewski, T.
dc.contributor.authorBarchas, J.D.
dc.contributor.authorBarnes, M.R.
dc.contributor.authorBarrett, T.B.
dc.contributor.authorBass, N.
dc.contributor.authorBattaglia, A.
dc.contributor.authorBauer, M.
dc.contributor.authorBayés, M.
dc.contributor.authorBellivier, F.
dc.contributor.authorBergen, S.E.
dc.contributor.authorBerrettini, W.
dc.contributor.authorBetancur, C.
dc.contributor.authorBettecken, T.
dc.contributor.authorBiederman, J.
dc.contributor.authorBinder, E.B.
dc.contributor.authorBlack, D.W.
dc.contributor.authorBlackwood, D.H.R.
dc.contributor.authorBloss, C.S.
dc.contributor.authorBoehnke, M.
dc.contributor.authorBoomsma, D.I.
dc.contributor.authorBreen, G.
dc.contributor.authorBreuer, R.
dc.contributor.authorBruggeman, R.
dc.contributor.authorCormican, P.
dc.contributor.authorBuccola, N.G.
dc.contributor.authorBuitelaar, J.K.
dc.contributor.authorBunney, W.E.
dc.contributor.authorBuxbaum, J.D.
dc.contributor.authorByerley, W.F.
dc.contributor.authorByrne, E.M.
dc.contributor.authorCaesar, S.
dc.contributor.authorCahn, W.
dc.contributor.authorCantor, R.M.
dc.contributor.authorCasas, M.
dc.contributor.authorChakravarti, A.
dc.contributor.authorChambert, K.
dc.contributor.authorChoudhury, K.
dc.contributor.authorCichon, S.
dc.contributor.authorCloninger, C.R.
dc.contributor.authorCollier, D.A.
dc.contributor.authorCook, E.H.
dc.contributor.authorCoon, H.
dc.contributor.authorCormand, B.
dc.contributor.authorCorvin, A.
dc.contributor.authorCoryell, W.H.
dc.contributor.authorCraig, D.W.
dc.contributor.authorCraig, I.W.
dc.contributor.authorCrosbie, J.
dc.contributor.authorCuccaro, M.L.
dc.contributor.authorCurtis, D.
dc.contributor.authorCzamara, D.
dc.contributor.authorDatta, S.
dc.contributor.authorDawson, G.
dc.contributor.authorDay, R.
dc.contributor.authorDe Geus, E.J.
dc.contributor.authorDegenhardt, F.
dc.contributor.authorDjurovic, S.
dc.contributor.authorDonohoe, G.J.
dc.contributor.authorDoyle, A.E.
dc.contributor.authorDuan, J.
dc.contributor.authorDudbridge, F.
dc.contributor.authorDuketis, E.
dc.contributor.authorEbstein, R.P.
dc.contributor.authorEdenberg, H.J.
dc.contributor.authorElia, J.
dc.contributor.authorEnnis, S.
dc.contributor.authorEtain, B.
dc.contributor.authorFanous, A.
dc.contributor.authorFarmer, A.E.
dc.contributor.authorFerrier, I.N.
dc.contributor.authorFlickinger, M.
dc.contributor.authorFombonne, E.
dc.contributor.authorForoud, T.
dc.contributor.authorFrank, J.
dc.contributor.authorFranke, B.
dc.contributor.authorFraser, C.
dc.contributor.authorFreedman, R.
dc.contributor.authorFreimer, N.B.
dc.contributor.authorFreitag, C.M.
dc.contributor.authorFriedl, M.
dc.contributor.authorFrisén, L.
dc.contributor.authorGallagher, L.
dc.contributor.authorGejman, P.V.
dc.contributor.authorGeorgieva, L.
dc.contributor.authorGershon, E.S.
dc.contributor.authorGeschwind, D.H.
dc.contributor.authorGiegling, I.
dc.contributor.authorGill, M.
dc.contributor.authorGordon, S.D.
dc.contributor.authorGordon-Smith, K.
dc.contributor.authorGreen, E.K.
dc.contributor.authorGreenwood, T.A.
dc.contributor.authorGrice, D.E.
dc.contributor.authorGross, M.
dc.contributor.authorGrozeva, D.
dc.contributor.authorGuan, W.
dc.contributor.authorGurling, H.
dc.contributor.authorDe Haan, L.
dc.contributor.authorHaines, J.L.
dc.contributor.authorHakonarson, H.
dc.contributor.authorHallmayer, J.
dc.contributor.authorHamilton, S.P.
dc.contributor.authorHamshere, M.L.
dc.contributor.authorHansen, T.F.
dc.contributor.authorHartmann, A.M.
dc.contributor.authorHautzinger, M.
dc.contributor.authorHeath, A.C.
dc.contributor.authorHenders, A.K.
dc.contributor.authorHerms, S.
dc.contributor.authorHickie, I.B.
dc.contributor.authorHipolito, M.
dc.contributor.authorHoefels, S.
dc.contributor.authorHolmans, P.A.
dc.contributor.authorHolsboer, F.
dc.contributor.authorHoogendijk, W.J.
dc.contributor.authorHottenga, J.-J.
dc.contributor.authorHultman, C.M.
dc.contributor.authorHus, V.
dc.contributor.authorIngason, A.
dc.contributor.authorIsing, M.
dc.contributor.authorJamain, S.
dc.contributor.authorJones, E.G.
dc.contributor.authorJones, I.
dc.contributor.authorJones, L.
dc.contributor.authorTzeng, J.-Y.
dc.contributor.authorKähler, A.K.
dc.contributor.authorKahn, R.S.
dc.contributor.authorKandaswamy, R.
dc.contributor.authorKeller, M.C.
dc.contributor.authorKennedy, J.L.
dc.contributor.authorKenny, E.
dc.contributor.authorKent, L.
dc.contributor.authorKim, Y.
dc.contributor.authorKirov, G.K.
dc.contributor.authorKlauck, S.M.
dc.contributor.authorKlei, L.
dc.contributor.authorKnowles, J.A.
dc.contributor.authorKohli, M.A.
dc.contributor.authorKoller, D.L.
dc.contributor.authorKonte, B.
dc.contributor.authorKorszun, A.
dc.contributor.authorKrabbendam, L.
dc.contributor.authorKrasucki, R.
dc.contributor.authorKuntsi, J.
dc.contributor.authorKwan, P.
dc.contributor.authorLandén, M.
dc.contributor.authorLångström, N.
dc.contributor.authorLathrop, M.
dc.contributor.authorLawrence, J.
dc.contributor.authorLawson, W.B.
dc.contributor.authorLeboyer, M.
dc.contributor.authorLedbetter, D.H.
dc.contributor.authorLee, P.H.
dc.contributor.authorLencz, T.
dc.contributor.authorLesch, K.-P.
dc.contributor.authorLevinson, D.F.
dc.contributor.authorLewis, C.M.
dc.contributor.authorLi, J.
dc.contributor.authorLichtenstein, P.
dc.contributor.authorLieberman, J.A.
dc.contributor.authorLin, D.-Y.
dc.contributor.authorLinszen, D.H.
dc.contributor.authorLiu, C.
dc.contributor.authorLohoff, F.W.
dc.contributor.authorLoo, S.K.
dc.contributor.authorLord, C.
dc.contributor.authorLowe, J.K.
dc.contributor.authorLucae, S.
dc.contributor.authorMacintyre, D.J.
dc.contributor.authorMadden, P.A.F.
dc.contributor.authorMaestrini, E.
dc.contributor.authorMagnusson, P.K.E.
dc.contributor.authorMahon, P.B.
dc.contributor.authorMaier, W.
dc.contributor.authorMalhotra, A.K.
dc.contributor.authorMane, S.M.
dc.contributor.authorMartin, C.L.
dc.contributor.authorMartin, N.G.
dc.contributor.authorMattheisen, M.
dc.contributor.authorMatthews, K.
dc.contributor.authorMattingsdal, M.
dc.contributor.authorMccarroll, S.A.
dc.contributor.authorMcghee, K.A.
dc.contributor.authorMcgough, J.J.
dc.contributor.authorMcgrath, P.J.
dc.contributor.authorMcguffin, P.
dc.contributor.authorMcinnis, M.G.
dc.contributor.authorMcintosh, A.
dc.contributor.authorMckinney, R.
dc.contributor.authorMclean, A.W.
dc.contributor.authorMcmahon, F.J.
dc.contributor.authorMcmahon, W.M.
dc.contributor.authorMcquillin, A.
dc.contributor.authorMedeiros, H.
dc.contributor.authorMedland, S.E.
dc.contributor.authorMeier, S.
dc.contributor.authorMelle, I.
dc.contributor.authorMeng, F.
dc.contributor.authorMeyer, J.
dc.contributor.authorMiddeldorp, C.M.
dc.contributor.authorMiddleton, L.
dc.contributor.authorMilanova, V.
dc.contributor.authorMiranda, A.
dc.contributor.authorMonaco, A.P.
dc.contributor.authorMontgomery, G.W.
dc.contributor.authorMoran, J.L.
dc.contributor.authorMoreno-De-Luca, D.
dc.contributor.authorMorken, G.
dc.contributor.authorMorris, D.W.
dc.contributor.authorMorrow, E.M.
dc.contributor.authorMoskvina, V.
dc.contributor.authorMuglia, P.
dc.contributor.authorMühleisen, T.W.
dc.contributor.authorMuir, W.J.
dc.contributor.authorMüller-Myhsok, B.
dc.contributor.authorMurtha, M.
dc.contributor.authorMyers, R.M.
dc.contributor.authorMyin-Germeys, I.
dc.contributor.authorNeale, M.C.
dc.contributor.authorNelson, S.F.
dc.contributor.authorNievergelt, C.M.
dc.contributor.authorNikolov, I.
dc.contributor.authorNimgaonkar, V.
dc.contributor.authorNolen, W.A.
dc.contributor.authorNöthen, M.M.
dc.contributor.authorNurnberger, J.I.
dc.contributor.authorNwulia, E.A.
dc.contributor.authorNyholt, D.R.
dc.contributor.authorO'dushlaine, C.
dc.contributor.authorOades, R.D.
dc.contributor.authorOlincy, A.
dc.contributor.authorOliveira, G.
dc.contributor.authorOlsen, L.
dc.contributor.authorOphoff, R.A.
dc.contributor.authorOsby, U.
dc.contributor.authorOwen, M.J.
dc.contributor.authorPalotie, A.
dc.contributor.authorParr, J.R.
dc.contributor.authorPaterson, A.D.
dc.contributor.authorPato, C.N.
dc.contributor.authorPato, M.T.
dc.contributor.authorPenninx, B.W.
dc.contributor.authorPergadia, M.L.
dc.contributor.authorPericak-Vance, M.A.
dc.contributor.authorPickard, B.S.
dc.contributor.authorPimm, J.
dc.contributor.authorPiven, J.
dc.contributor.authorPosthuma, D.
dc.contributor.authorPotash, J.B.
dc.contributor.authorPoustka, F.
dc.contributor.authorPropping, P.
dc.contributor.authorPuri, V.
dc.contributor.authorQuested, D.J.
dc.contributor.authorQuinn, E.M.
dc.contributor.authorRamos-Quiroga, J.A.
dc.contributor.authorRasmussen, H.B.
dc.contributor.authorRaychaudhuri, S.
dc.contributor.authorRehnström, K.
dc.contributor.authorReif, A.
dc.contributor.authorRibasés, M.
dc.contributor.authorRice, J.P.
dc.contributor.authorRietschel, M.
dc.contributor.authorRoeder, K.
dc.contributor.authorRoeyers, H.
dc.contributor.authorRossin, L.
dc.contributor.authorRothenberger, A.
dc.contributor.authorRouleau, G.
dc.contributor.authorRuderfer, D.
dc.contributor.authorRujescu, D.
dc.contributor.authorSanders, A.R.
dc.contributor.authorSanders, S.J.
dc.contributor.authorSantangelo, S.L.
dc.contributor.authorSergeant, J.A.
dc.contributor.authorSchachar, R.
dc.contributor.authorSchalling, M.
dc.contributor.authorSchatzberg, A.F.
dc.contributor.authorScheftner, W.A.
dc.contributor.authorSchellenberg, G.D.
dc.contributor.authorScherer, S.W.
dc.contributor.authorSchork, N.J.
dc.contributor.authorSchulze, T.G.
dc.contributor.authorSchumacher, J.
dc.contributor.authorSchwarz, M.
dc.contributor.authorScolnick, E.
dc.contributor.authorScott, L.J.
dc.contributor.authorShi, J.
dc.contributor.authorShilling, P.D.
dc.contributor.authorShyn, S.I.
dc.contributor.authorSilverman, J.M.
dc.contributor.authorSlager, S.L.
dc.contributor.authorSmalley, S.L.
dc.contributor.authorSmit, J.H.
dc.contributor.authorSmith, E.N.
dc.contributor.authorSonuga-Barke, E.J.S.
dc.contributor.authorSt. Clair, D.
dc.contributor.authorState, M.
dc.contributor.authorSteffens, M.
dc.contributor.authorSteinhausen, H.-C.
dc.contributor.authorStrauss, J.S.
dc.contributor.authorStrohmaier, J.
dc.contributor.authorStroup, T.S.
dc.contributor.authorSutcliffe, J.S.
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dc.contributor.authorSzelinger, S.
dc.contributor.authorThirumalai, S.
dc.contributor.authorThompson, R.C.
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dc.contributor.authorVan Grootheest, G.
dc.contributor.authorVan Os, J.
dc.contributor.authorVicente, A.M.
dc.contributor.authorVieland, V.J.
dc.contributor.authorVincent, J.B.
dc.contributor.authorVisscher, P.M.
dc.contributor.authorWalsh, C.A.
dc.contributor.authorWassink, T.H.
dc.contributor.authorWatson, S.J.
dc.contributor.authorWeissman, M.M.
dc.contributor.authorWerge, T.
dc.contributor.authorWienker, T.F.
dc.contributor.authorWijsman, E.M.
dc.contributor.authorWillemsen, G.
dc.contributor.authorWilliams, N.
dc.contributor.authorWillsey, A.J.
dc.contributor.authorWitt, S.H.
dc.contributor.authorXu, W.
dc.contributor.authorYoung, A.H.
dc.contributor.authorYu, T.W.
dc.contributor.authorZammit, S.
dc.contributor.authorZandi, P.P.
dc.contributor.authorZhang, P.
dc.contributor.authorZitman, F.G.
dc.contributor.authorZöllner, S.
dc.contributor.authorDevlin, B.
dc.contributor.authorKelsoe, J.R.
dc.contributor.authorSklar, P.
dc.contributor.authorDaly, M.J.
dc.contributor.authorO'donovan, M.C.
dc.contributor.authorCraddock, N.
dc.contributor.authorSullivan, P.F.
dc.contributor.authorSmoller, J.W.
dc.contributor.authorKendler, K.S.
dc.contributor.authorWray, N.R.
dc.date.accessioned2016-10-19T08:42:53Z
dc.date.available2016-10-19T08:42:53Z
dc.date.issued2013-09
dc.identifier.citationLee, S.H., Ripke, S., Neale, B.M., Faraone, S.V., Purcell, S.M., Perlis, R.H., Mowry, B.J., Thapar, A., Goddard, M.E., Witte, J.S., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen, O.A., Anjorin, A., Anney, R., Anttila, V., Arking, D.E., Asherson, P., Azevedo, M.H., Backlund, L., Badner, J.A., Bailey, A.J., Banaschewski, T., Barchas, J.D., Barnes, M.R., Barrett, T.B., Bass, N., Battaglia, A., Bauer, M., Bayés, M., Bellivier, F., Bergen, S.E., Berrettini, W., Betancur, C., Bettecken, T., Biederman, J., Binder, E.B., Black, D.W., Blackwood, D.H.R., Bloss, C.S., Boehnke, M., Boomsma, D.I., Breen, G., Breuer, R., Bruggeman, R., Cormican, P., Buccola, N.G., Buitelaar, J.K., Bunney, W.E., Buxbaum, J.D., Byerley, W.F., Byrne, E.M., Caesar, S., Cahn, W., Cantor, R.M., Casas, M., Chakravarti, A., Chambert, K., Choudhury, K., Cichon, S., Cloninger, C.R., Collier, D.A., Cook, E.H., Coon, H., Cormand, B., Corvin, A., Coryell, W.H., Craig, D.W., Craig, I.W., Crosbie, J., Cuccaro, M.L., Curtis, D., Czamara, D., Datta, S., Dawson, G., Day, R., De Geus, E.J., Degenhardt, F., Djurovic, S., Donohoe, G.J., Doyle, A.E., Duan, J., Dudbridge, F., Duketis, E., Ebstein, R.P., Edenberg, H.J., Elia, J., Ennis, S., Etain, B., Fanous, A., Farmer, A.E., Ferrier, I.N., Flickinger, M., Fombonne, E., Foroud, T., Frank, J., Franke, B., Fraser, C., Freedman, R., Freimer, N.B., Freitag, C.M., Friedl, M., Frisén, L., Gallagher, L., Gejman, P.V., Georgieva, L., Gershon, E.S., Geschwind, D.H., Giegling, I., Gill, M., Gordon, S.D., Gordon-Smith, K., Green, E.K., Greenwood, T.A., Grice, D.E., Gross, M., Grozeva, D., Guan, W., Gurling, H., De Haan, L., Haines, J.L., Hakonarson, H., Hallmayer, J., Hamilton, S.P., Hamshere, M.L., Hansen, T.F., Hartmann, A.M., Hautzinger, M., Heath, A.C., Henders, A.K., Herms, S., Hickie, I.B., Hipolito, M., Hoefels, S., Holmans, P.A., Holsboer, F., Hoogendijk, W.J., Hottenga, J.-J., Hultman, C.M., Hus, V., Ingason, A., Ising, M., Jamain, S., Jones, E.G., Jones, I., Jones, L., Tzeng, J.-Y., Kähler, A.K., Kahn, R.S., Kandaswamy, R., Keller, M.C., Kennedy, J.L., Kenny, E., Kent, L., Kim, Y., Kirov, G.K., Klauck, S.M., Klei, L., Knowles, J.A., Kohli, M.A., Koller, D.L., Konte, B., Korszun, A., Krabbendam, L., Krasucki, R., Kuntsi, J., Kwan, P., Landén, M., Långström, N., Lathrop, M., Lawrence, J., Lawson, W.B., Leboyer, M., Ledbetter, D.H., Lee, P.H., Lencz, T., Lesch, K.-P., Levinson, D.F., Lewis, C.M., Li, J., Lichtenstein, P., Lieberman, J.A., Lin, D.-Y., Linszen, D.H., Liu, C., Lohoff, F.W., Loo, S.K., Lord, C., Lowe, J.K., Lucae, S., Macintyre, D.J., Madden, P.A.F., Maestrini, E., Magnusson, P.K.E., Mahon, P.B., Maier, W., Malhotra, A.K., Mane, S.M., Martin, C.L., Martin, N.G., Mattheisen, M., Matthews, K., Mattingsdal, M., Mccarroll, S.A., Mcghee, K.A., Mcgough, J.J., Mcgrath, P.J., Mcguffin, P., Mcinnis, M.G., Mcintosh, A., Mckinney, R., Mclean, A.W., Mcmahon, F.J., Mcmahon, W.M., Mcquillin, A., Medeiros, H., Medland, S.E., Meier, S., Melle, I., Meng, F., Meyer, J., Middeldorp, C.M., Middleton, L., Milanova, V., Miranda, A., Monaco, A.P., Montgomery, G.W., Moran, J.L., Moreno-De-Luca, D., Morken, G., Morris, D.W., Morrow, E.M., Moskvina, V., Muglia, P., Mühleisen, T.W., Muir, W.J., Müller-Myhsok, B., Murtha, M., Myers, R.M., Myin-Germeys, I., Neale, M.C., Nelson, S.F., Nievergelt, C.M., Nikolov, I., Nimgaonkar, V., Nolen, W.A., Nöthen, M.M., Nurnberger, J.I., Nwulia, E.A., Nyholt, D.R., O'dushlaine, C., Oades, R.D., Olincy, A., Oliveira, G., Olsen, L., Ophoff, R.A., Osby, U., Owen, M.J., Palotie, A., Parr, J.R., Paterson, A.D., Pato, C.N., Pato, M.T., Penninx, B.W., Pergadia, M.L., Pericak-Vance, M.A., Pickard, B.S., Pimm, J., Piven, J., Posthuma, D., Potash, J.B., Poustka, F., Propping, P., Puri, V., Quested, D.J., Quinn, E.M., Ramos-Quiroga, J.A., Rasmussen, H.B., Raychaudhuri, S., Rehnström, K., Reif, A., Ribasés, M., Rice, J.P., Rietschel, M., Roeder, K., Roeyers, H., Rossin, L., Rothenberger, A., Rouleau, G., Ruderfer, D., Rujescu, D., Sanders, A.R., Sanders, S.J., Santangelo, S.L., Sergeant, J.A., Schachar, R., Schalling, M., Schatzberg, A.F., Scheftner, W.A., Schellenberg, G.D., Scherer, S.W., Schork, N.J., Schulze, T.G., Schumacher, J., Schwarz, M., Scolnick, E., Scott, L.J., Shi, J., Shilling, P.D., Shyn, S.I., Silverman, J.M., Slager, S.L., Smalley, S.L., Smit, J.H., Smith, E.N., Sonuga-Barke, E.J.S., St. Clair, D., State, M., Steffens, M., Steinhausen, H.-C., Strauss, J.S., Strohmaier, J., Stroup, T.S., Sutcliffe, J.S., Szatmari, P., Szelinger, S., Thirumalai, S., Thompson, R.C., Todorov, A.A., Tozzi, F., Treutlein, J., Uhr, M., Van Den Oord, E.J.C.G., Van Grootheest, G., Van Os, J., Vicente, A.M., Vieland, V.J., Vincent, J.B., Visscher, P.M., Walsh, C.A., Wassink, T.H., Watson, S.J., Weissman, M.M., Werge, T., Wienker, T.F., Wijsman, E.M., Willemsen, G., Williams, N., Willsey, A.J., Witt, S.H., Xu, W., Young, A.H., Yu, T.W., Zammit, S., Zandi, P.P., Zhang, P., Zitman, F.G., Zöllner, S., Devlin, B., Kelsoe, J.R., Sklar, P., Daly, M.J., O'donovan, M.C., Craddock, N., Sullivan, P.F., Smoller, J.W., Kendler, K.S., Wray, N.R. (2013-09). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45 (9) : 984-994. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2711
dc.identifier.issn10614036
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/128593
dc.description.abstractMost psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. © 2013 Nature America, Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ng.2711
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPSYCHOLOGY
dc.description.doi10.1038/ng.2711
dc.description.sourcetitleNature Genetics
dc.description.volume45
dc.description.issue9
dc.description.page984-994
dc.description.codenNGENE
dc.identifier.isiut000323748200007
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