Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0078468
DC FieldValue
dc.titleContribution of Soft Substrates to Malignancy and Tumor Suppression during Colon Cancer Cell Division
dc.contributor.authorRabineau, M.
dc.contributor.authorKocgozlu, L.
dc.contributor.authorDujardin, D.
dc.contributor.authorSenger, B.
dc.contributor.authorHaikel, Y.
dc.contributor.authorVoegel, J.-C.
dc.contributor.authorFreund, J.-N.
dc.contributor.authorSchaaf, P.
dc.contributor.authorLavalle, P.
dc.contributor.authorVautier, D.
dc.date.accessioned2016-10-18T06:27:16Z
dc.date.available2016-10-18T06:27:16Z
dc.date.issued2013-10-22
dc.identifier.citationRabineau, M., Kocgozlu, L., Dujardin, D., Senger, B., Haikel, Y., Voegel, J.-C., Freund, J.-N., Schaaf, P., Lavalle, P., Vautier, D. (2013-10-22). Contribution of Soft Substrates to Malignancy and Tumor Suppression during Colon Cancer Cell Division. PLoS ONE 8 (10) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0078468
dc.identifier.issn19326203
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/128520
dc.description.abstractIn colon cancer, a highly aggressive disease, progression through the malignant sequence is accompanied by increasingly numerous chromosomal rearrangements. To colonize target organs, invasive cells cross several tissues of various elastic moduli. Whether soft tissue increases malignancy or in contrast limits invasive colon cell spreading remains an open question. Using polyelectrolyte multilayer films mimicking microenvironments of various elastic moduli, we revealed that human SW480 colon cancer cells displayed increasing frequency in chromosomal segregation abnormalities when cultured on substrates with decreasing stiffness. Our results show that, although decreasing stiffness correlates with increased cell lethality, a significant proportion of SW480 cancer cells did escape from the very soft substrates, even when bearing abnormal chromosome segregation, achieve mitosis and undergo a new cycle of replication in contrast to human colonic HCoEpiC cells which died on soft substrates. This observation opens the possibility that the ability of cancer cells to overcome defects in chromosome segregation on very soft substrates could contribute to increasing chromosomal rearrangements and tumor cell aggressiveness. © 2013 Rabineau et al.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0078468
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMECHANOBIOLOGY INSTITUTE
dc.description.doi10.1371/journal.pone.0078468
dc.description.sourcetitlePLoS ONE
dc.description.volume8
dc.description.issue10
dc.description.page-
dc.description.codenPOLNC
dc.identifier.isiut000326034500089
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on Jan 28, 2022

WEB OF SCIENCETM
Citations

2
checked on Jan 28, 2022

Page view(s)

70
checked on Jan 27, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.