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Please use this identifier to cite or link to this item: https://doi.org/10.1136/bmj.f3039
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dc.titleEffect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: Double blind randomised controlled trial
dc.contributor.authorSedyaningsih, E.R.
dc.contributor.authorMalik, M.S.
dc.contributor.authorSetiawaty, V.
dc.contributor.authorTrihono, T.
dc.contributor.authorBurhan, E.
dc.contributor.authorAditama, T.Y.
dc.contributor.authorSoepandi, P.Z.
dc.contributor.authorPartakusuma, L.G.
dc.contributor.authorSutiyoso, A.P.
dc.contributor.authorPriatni, I.
dc.contributor.authorJusuf, H.
dc.contributor.authorPranggono, E.H.
dc.contributor.authorSoeroto, A.Y.
dc.contributor.authorSetiabudi, D.
dc.contributor.authorSomasetia, D.H.
dc.contributor.authorSudarwati, S.
dc.contributor.authorMaskoen, T.T.
dc.contributor.authorHartantri, Y.
dc.contributor.authorParwati, I.
dc.contributor.authorGiriputro, S.
dc.contributor.authorMurniati, D.
dc.contributor.authorSirait, S.M.
dc.contributor.authorSoetanto, T.
dc.contributor.authorSulastri, S.
dc.contributor.authorAgus, R.
dc.contributor.authorRusli, A.
dc.contributor.authorWiweka, S.
dc.contributor.authorWignall, S.
dc.contributor.authorBaird, K.
dc.contributor.authorSafika, I.
dc.contributor.authorSangsajja, C.
dc.contributor.authorManosuthi, W.
dc.contributor.authorSutha, P.
dc.contributor.authorChuchottaworn, C.
dc.contributor.authorSansayunh, P.
dc.contributor.authorBangpattanasiri, K.
dc.contributor.authorTaylor, W.R.J.
dc.contributor.authorStepniewska, K.
dc.contributor.authorFukuda, C.
dc.contributor.authorLindegardh, N.
dc.contributor.authorWhite, N.
dc.contributor.authorDay, N.
dc.contributor.authorChotpitayasunondh, T.
dc.contributor.authorSuntarattiwong, P.
dc.contributor.authorChantbuddhiwet, U.
dc.contributor.authorNetsawang, S.
dc.contributor.authorChokephaibulkit, K.
dc.contributor.authorVanprapar, N.
dc.contributor.authorPrasitsuebsai, W.
dc.contributor.authorWittawatmongkol, O.
dc.contributor.authorAnekthananon, T.
dc.contributor.authorRatanasuwan, W.
dc.contributor.authorRongrungruang, Y.
dc.contributor.authorPuthavathana, P.
dc.contributor.authorTambyah, P.A.
dc.contributor.authorLeo, Y.-S.
dc.contributor.authorFisher, D.
dc.contributor.authorChai, L.
dc.contributor.authorLee, L.
dc.contributor.authorLin, R.
dc.contributor.authorMinh, N.N.Q.
dc.contributor.authorKhanh, T.H.
dc.contributor.authorThoa, L.P.K.
dc.contributor.authorTuan, L.A.
dc.contributor.authorDung, T.T.M.
dc.contributor.authorHa, L.T.T.
dc.contributor.authorQui, L.M.
dc.contributor.authorThinh, L.Q.
dc.contributor.authorAnh, N.N.T.
dc.contributor.authorTuan, T.A.
dc.contributor.authorNhien, T.H.
dc.contributor.authorPhuong, B.P.
dc.contributor.authorQui, P.T.
dc.contributor.authorThy, T.C.
dc.contributor.authorVu, B.X.
dc.contributor.authorTinh, L.B.B.
dc.contributor.authorThanh, D.T.
dc.contributor.authorKhanh, V.P.
dc.contributor.authorViet, D.C.
dc.contributor.authorThuy, T.T.
dc.contributor.authorBao, V.Q.
dc.contributor.authorTrung, L.N.N.
dc.contributor.authorThoa, H.T.K.
dc.contributor.authorAnh, T.T.N.
dc.contributor.authorLoan, T.T.T.
dc.contributor.authorHuong, T.Q.
dc.contributor.authorLe, N.T.H.
dc.contributor.authorViet, H.L.
dc.contributor.authorTuan, H.M.
dc.contributor.authorHa, N.T.T.
dc.contributor.authorChau, N.V.V.
dc.contributor.authorTruong, N.T.
dc.contributor.authorThao, L.T.T.
dc.contributor.authorPhong, N.T.
dc.contributor.authorHien, P.T.D.
dc.contributor.authorMen, P.T.H.
dc.contributor.authorTam, C.T.
dc.contributor.authorDiet, T.V.
dc.contributor.authorHao, N.V.
dc.contributor.authorVan Kinh, N.
dc.contributor.authorHien, N.D.
dc.contributor.authorHa, N.H.
dc.contributor.authorVan Tuyet, H.
dc.contributor.authorPhuc, N.N.
dc.contributor.authorThai, N.Q.
dc.contributor.authorChinh, L.Q.
dc.contributor.authorCap, N.T.
dc.contributor.authorPhu, V.D.
dc.contributor.authorNinh, T.T.H.
dc.contributor.authorTrung, N.V.
dc.contributor.authorLiem, N.T.
dc.contributor.authorHuy, B.V.
dc.contributor.authorSan, L.T.
dc.contributor.authorPhuc, P.H.
dc.contributor.authorTuan, H.A.
dc.contributor.authorTung, C.V.
dc.contributor.authorThanh, D.T.M.
dc.contributor.authorNgoc, L.X.
dc.contributor.authorHung, P.V.
dc.contributor.authorHung, D.V.
dc.contributor.authorHien, P.T.
dc.contributor.authorBeigel, J.
dc.contributor.authorPolis, M.
dc.contributor.authorHiggs, E.
dc.contributor.authorNgoc, N.M.
dc.contributor.authorNgan, T.T.
dc.contributor.authorTham, N.T.
dc.contributor.authorTam, D.T.
dc.contributor.authorBKrong, N.T.T.C.
dc.contributor.authorUyen, L.T.T.
dc.contributor.authorHang, V.T.T.
dc.contributor.authorThanh, T.T.
dc.contributor.authorBryant, J.E.
dc.contributor.authorHa, D.Q.
dc.contributor.authorHien, V.M.
dc.contributor.authorNguyet, L.A.
dc.contributor.authorNhu, L.N.T.
dc.contributor.authorKhuong, H.D.
dc.contributor.authorStockwell, E.
dc.contributor.authorMerson, L.
dc.contributor.authorFarrar, J.J.
dc.contributor.authorHayden, F.
dc.contributor.authorHien, T.T.
dc.contributor.authorFox, A.
dc.contributor.authorDe Jong, M.D.
dc.contributor.authorHorby, P.
dc.contributor.authorWertheim, H.L.
dc.contributor.authorVan Doorn, H.R.
dc.date.accessioned2016-09-07T08:58:42Z
dc.date.available2016-09-07T08:58:42Z
dc.date.issued2013-06-08
dc.identifier.citationSedyaningsih, E.R., Malik, M.S., Setiawaty, V., Trihono, T., Burhan, E., Aditama, T.Y., Soepandi, P.Z., Partakusuma, L.G., Sutiyoso, A.P., Priatni, I., Jusuf, H., Pranggono, E.H., Soeroto, A.Y., Setiabudi, D., Somasetia, D.H., Sudarwati, S., Maskoen, T.T., Hartantri, Y., Parwati, I., Giriputro, S., Murniati, D., Sirait, S.M., Soetanto, T., Sulastri, S., Agus, R., Rusli, A., Wiweka, S., Wignall, S., Baird, K., Safika, I., Sangsajja, C., Manosuthi, W., Sutha, P., Chuchottaworn, C., Sansayunh, P., Bangpattanasiri, K., Taylor, W.R.J., Stepniewska, K., Fukuda, C., Lindegardh, N., White, N., Day, N., Chotpitayasunondh, T., Suntarattiwong, P., Chantbuddhiwet, U., Netsawang, S., Chokephaibulkit, K., Vanprapar, N., Prasitsuebsai, W., Wittawatmongkol, O., Anekthananon, T., Ratanasuwan, W., Rongrungruang, Y., Puthavathana, P., Tambyah, P.A., Leo, Y.-S., Fisher, D., Chai, L., Lee, L., Lin, R., Minh, N.N.Q., Khanh, T.H., Thoa, L.P.K., Tuan, L.A., Dung, T.T.M., Ha, L.T.T., Qui, L.M., Thinh, L.Q., Anh, N.N.T., Tuan, T.A., Nhien, T.H., Phuong, B.P., Qui, P.T., Thy, T.C., Vu, B.X., Tinh, L.B.B., Thanh, D.T., Khanh, V.P., Viet, D.C., Thuy, T.T., Bao, V.Q., Trung, L.N.N., Thoa, H.T.K., Anh, T.T.N., Loan, T.T.T., Huong, T.Q., Le, N.T.H., Viet, H.L., Tuan, H.M., Ha, N.T.T., Chau, N.V.V., Truong, N.T., Thao, L.T.T., Phong, N.T., Hien, P.T.D., Men, P.T.H., Tam, C.T., Diet, T.V., Hao, N.V., Van Kinh, N., Hien, N.D., Ha, N.H., Van Tuyet, H., Phuc, N.N., Thai, N.Q., Chinh, L.Q., Cap, N.T., Phu, V.D., Ninh, T.T.H., Trung, N.V., Liem, N.T., Huy, B.V., San, L.T., Phuc, P.H., Tuan, H.A., Tung, C.V., Thanh, D.T.M., Ngoc, L.X., Hung, P.V., Hung, D.V., Hien, P.T., Beigel, J., Polis, M., Higgs, E., Ngoc, N.M., Ngan, T.T., Tham, N.T., Tam, D.T., BKrong, N.T.T.C., Uyen, L.T.T., Hang, V.T.T., Thanh, T.T., Bryant, J.E., Ha, D.Q., Hien, V.M., Nguyet, L.A., Nhu, L.N.T., Khuong, H.D., Stockwell, E., Merson, L., Farrar, J.J., Hayden, F., Hien, T.T., Fox, A., De Jong, M.D., Horby, P., Wertheim, H.L., Van Doorn, H.R. (2013-06-08). Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: Double blind randomised controlled trial. BMJ (Online) 346 (7911) : -. ScholarBank@NUS Repository. https://doi.org/10.1136/bmj.f3039
dc.identifier.issn17561833
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/127126
dc.description.abstractObjective: To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza. Design: Double blind randomised trial. Setting: Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam. Participants: Patients aged ≥1 year admitted to hospital with confirmed severe influenza. Interventions: Oral oseltamivir at double dose (150 mg twice a day/paediatric equivalent) versus standard dose (75 mg twice a day/paediatric equivalent). Main outcome measure: Viral status according to reverse transcriptase polymerase chain reaction (RT-PCR) for influenza RNA in nasal and throat swabs on day five. Results: Of 326 patients (including 246 (75.5%) children aged
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1136/bmj.f3039
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1136/bmj.f3039
dc.description.sourcetitleBMJ (Online)
dc.description.volume346
dc.description.issue7911
dc.description.page-
dc.description.codenBMJOA
dc.identifier.isiut000319948800004
Appears in Collections:Staff Publications

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