Please use this identifier to cite or link to this item:
|Title:||Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor||Authors:||Zhou, X.E.
|Issue Date:||19-Mar-2010||Citation:||Zhou, X.E., Suino-Powell, K.M., Li, J., He, Y., MacKeigan, J.P., Melcher, K., Yong, E.-L., Xu, H.E. (2010-03-19). Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor. Journal of Biological Chemistry 285 (12) : 9161-9171. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M109.085779||Abstract:||Transcription activation by androgen receptor (AR), which depends on recruitment of coactivators, is required for the initiation and progression of prostate cancer, yet the mechanisms of how hormone-activated AR interacts with coactivators remain unclear. This is because AR, unlike any other nuclear receptor, prefers its own N-terminal FXXLF motif to the canonical LXXLL motifs of coactivators. Through biochemical and crystallographic studies, we identify that steroid receptor coactivator-3 (SRC3) (also named as amplified in breast cancer-1 or AIB1) interacts strongly with AR via synergistic binding of its first and third LXXLL motifs. Mutagenesis and functional studies confirm that SRC3 is a preferred coactivator for hormone-activated AR. Importantly, AR mutations found in prostate cancer patients correlate with their binding potency to SRC3, corroborating with the emerging role of SRC3 as a prostate cancer oncogene. These results provide a molecular mechanism for the selective utilization of SRC3 by hormone-activated AR, and they link the functional relationship between AR and SRC3 to the development and growth of prostate cancer. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc.||Source Title:||Journal of Biological Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/127000||ISSN:||00219258||DOI:||10.1074/jbc.M109.085779|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 18, 2021
WEB OF SCIENCETM
checked on Jan 11, 2021
checked on Jan 16, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.