Please use this identifier to cite or link to this item: https://doi.org/10.1017/S0950268812000337
Title: ST22 and ST239 MRSA duopoly in Singaporean hospitals: 2006-2010
Authors: Teo, J.
Tan, T.Y.
Hon, P.Y.
Lee, W.
Koh, T.H.
Krishnan, P.
Hsu, L.Y. 
Keywords: Antibiotic resistance
bacterial typing
methicillin-resistant S. aureus (MRSA)
Issue Date: Jan-2013
Citation: Teo, J., Tan, T.Y., Hon, P.Y., Lee, W., Koh, T.H., Krishnan, P., Hsu, L.Y. (2013-01). ST22 and ST239 MRSA duopoly in Singaporean hospitals: 2006-2010. Epidemiology and Infection 141 (1) : 153-157. ScholarBank@NUS Repository. https://doi.org/10.1017/S0950268812000337
Abstract: SUMMARY Surveillance is integral for the monitoring and control of infectious diseases. We conducted prospective laboratory surveillance of methicillin-resistant Staphylococcus aureus (MRSA) in five Singaporean public-sector hospitals from 2006 to 2010, using WHONET 5.6 for data compilation and analysis. Molecular profiling using multilocus variable-number tandem-repeat analysis, staphylococcal cassette chromosome mec classification and multilocus sequence typing was performed for a random selection of isolates. Our results showed overall stable rates of infection and bacteraemia, although there was significant variance among the individual hospitals, with MRSA rates increasing in two smaller hospitals and showing a trend towards decreasing in the two largest hospitals. The proportion of blood isolates that are EMRSA-15 (ST22-IV) continued to increase over time, slowly replacing the multi-resistant ST239-III. A new MRSA clone - ST45-IV - is now responsible for a small subset of hospital infections locally. More effort is required in Singaporean hospitals in order to reduce the rates of MRSA infection significantly. Copyright © Cambridge University Press 2012.
Source Title: Epidemiology and Infection
URI: http://scholarbank.nus.edu.sg/handle/10635/126859
ISSN: 09502688
DOI: 10.1017/S0950268812000337
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