In vitro antibiotic synergy in extensively drug-resistant Acinetobacter baumannii: The effect of testing by time-kill, checkerboard, and etest methods

Please use this identifier to cite or link to this item: https://doi.org/10.1128/AAC.00850-10

Title:	In vitro antibiotic synergy in extensively drug-resistant Acinetobacter baumannii: The effect of testing by time-kill, checkerboard, and etest methods
Authors:	Tan, T.Y. Lim, T.P. Lee, W.H.L. Sasikala, S. Hsu, L.Y. Kwa, A.L.-H.
Issue Date:	Jan-2011
Citation:	Tan, T.Y., Lim, T.P., Lee, W.H.L., Sasikala, S., Hsu, L.Y., Kwa, A.L.-H. (2011-01). In vitro antibiotic synergy in extensively drug-resistant Acinetobacter baumannii: The effect of testing by time-kill, checkerboard, and etest methods. Antimicrobial Agents and Chemotherapy 55 (1) : 436-438. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.00850-10
Abstract:	This study examined the in vitro effects of polymyxin B, tigecycline, and rifampin combinations on 16 isolates of extensively drug-resistant Acinetobacter baumannii, including four polymyxin-resistant strains. In vitro synergy was demonstrated in 19 (40%) of a possible 48 isolate-antibiotic combinations by time-kill methods, 8 (17%) by checkerboard methods, and only 1 (2%) by Etest methods. There was only slight agreement between Etest and checkerboard methods and no agreement between results obtained by other methods. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Source Title:	Antimicrobial Agents and Chemotherapy
URI:	http://scholarbank.nus.edu.sg/handle/10635/126822
ISSN:	00664804
DOI:	10.1128/AAC.00850-10
Appears in Collections:	Staff Publications

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