Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.gie.2010.08.031
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dc.titleConfocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: A feasibility study
dc.contributor.authorLi, Z.
dc.contributor.authorYu, T.
dc.contributor.authorZuo, X.-L.
dc.contributor.authorGu, X.-M.
dc.contributor.authorZhou, C.-J.
dc.contributor.authorJi, R.
dc.contributor.authorLi, C.-Q.
dc.contributor.authorWang, P.
dc.contributor.authorZhang, T.-G.
dc.contributor.authorHo, K.-Y.
dc.contributor.authorLi, Y.-Q.
dc.date.accessioned2016-09-06T08:41:25Z
dc.date.available2016-09-06T08:41:25Z
dc.date.issued2010-12
dc.identifier.citationLi, Z., Yu, T., Zuo, X.-L., Gu, X.-M., Zhou, C.-J., Ji, R., Li, C.-Q., Wang, P., Zhang, T.-G., Ho, K.-Y., Li, Y.-Q. (2010-12). Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: A feasibility study. Gastrointestinal Endoscopy 72 (6) : 1146-1153. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gie.2010.08.031
dc.identifier.issn00165107
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126797
dc.description.abstractBackground Confocal laser endomicroscopy (CLE) is a novel endoscopic modality that allows subsurface analysis of the gastric mucosa during ongoing endoscopy. Several studies have reported that this technique is of value in the diagnosis of premalignant lesions in the GI tract, but as yet no investigations have reported its application in the analysis of gastric intraepithelial neoplasia (GIN). Objective To assess the feasibility of CLE for the identification and grading of GIN. Design Prospective double-blind feasibility study. Setting Qilu Hospital, Shandong University, Jinan, China. Patients CLE images of 33 patients were first evaluated to establish the diagnostic criteria for gastric lesions. Eligible patients were then prospectively investigated by CLE using the newly established criteria. Interventions All endoscopically suspicious lesions were examined by CLE, and CLE diagnoses were compared with corresponding histopathologic results. Main Outcome Measurements Sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of biopsy-proven intraepithelial neoplasia by per-lesion analysis. Results The sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of GIN were 77.8%, 81.8%, 4.28, and 0.27, respectively. The mean κ value for interobserver agreement for the diagnosis of GIN was 0.70 among endoscopists and 0.71 between endoscopist and GI pathologist. Intraepithelial neoplasia score
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.gie.2010.08.031
dc.sourceScopus
dc.subjectAbbreviations
dc.subjectCI
dc.subjectCLE
dc.subjectConfidence interval
dc.subjectConfocal laser endomicroscopy
dc.subjectGastric intraepithelial neoplasia
dc.subjectGIN
dc.subjectHGIN
dc.subjectHigh-grade intraepithelial neoplasia
dc.subjectINS
dc.subjectIntraepithelial neoplasia score
dc.subjectLGIN
dc.subjectLow-grade intraepithelial neoplasia
dc.subjectROC
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.gie.2010.08.031
dc.description.sourcetitleGastrointestinal Endoscopy
dc.description.volume72
dc.description.issue6
dc.description.page1146-1153
dc.description.codenGAENB
dc.identifier.isiut000285319000006
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