Please use this identifier to cite or link to this item: https://doi.org/10.3892/ol.2013.1262
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dc.titleCan quantifying free-circulating DNA in plasma be used to identify subjects with high-grade pre-invasive endobronchial lesions?
dc.contributor.authorVan Boerdonk, R.A.A.
dc.contributor.authorBrokx, H.A.P.
dc.contributor.authorLee, P.
dc.contributor.authorKooi, C.
dc.contributor.authorPostmus, P.E.
dc.contributor.authorSnijders, P.J.F.
dc.contributor.authorGrünberg, K.
dc.contributor.authorThunnissen, E.
dc.contributor.authorSutedja, T.G.
dc.contributor.authorDaniels, J.M.A.
dc.contributor.authorHeideman, D.A.M.
dc.date.accessioned2016-09-06T08:41:20Z
dc.date.available2016-09-06T08:41:20Z
dc.date.issued2013-10
dc.identifier.citationVan Boerdonk, R.A.A., Brokx, H.A.P., Lee, P., Kooi, C., Postmus, P.E., Snijders, P.J.F., Grünberg, K., Thunnissen, E., Sutedja, T.G., Daniels, J.M.A., Heideman, D.A.M. (2013-10). Can quantifying free-circulating DNA in plasma be used to identify subjects with high-grade pre-invasive endobronchial lesions?. Oncology Letters 5 (5) : 1591-1594. ScholarBank@NUS Repository. https://doi.org/10.3892/ol.2013.1262
dc.identifier.issn17921074
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126790
dc.description.abstractIncreased concentrations of free-circulating plasma DNA (cpDNA) are observed in patients with invasive cancer, including lung cancer. Whether cpDNA levels are elevated in subjects with high-grade pre-invasive lesions of lung squamous cell carcinoma (SqCC) and whether its detection may be of value for identifying subjects at the highest risk of developing lung SqCC is currently unknown. The present study assessed cpDNA levels in subjects with high- and low--grade pre-invasive squamous endobronchial lesions relative to patients with clinically overt lung SqCC and healthy controls using real-time quantitative PCR methodology. The median cpDNA levels of the patients with invasive lung SqCC (n=16) were significantly higher compared with those of the healthy controls (n=16; P
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3892/ol.2013.1262
dc.sourceScopus
dc.subjectAutofluorescence bronchoscopy
dc.subjectCirculating plasma DNA
dc.subjectPremalignant endobronchial lesion
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.3892/ol.2013.1262
dc.description.sourcetitleOncology Letters
dc.description.volume5
dc.description.issue5
dc.description.page1591-1594
dc.identifier.isiut000318385500030
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