Please use this identifier to cite or link to this item: https://doi.org/10.1172/JCI70084
Title: B cells mediate chronic allograft rejection independently of antibody production
Authors: Zeng, Q.
Ng, Y.-H. 
Singh, T.
Jiang, K.
Sheriff, K.A.
Ippolito, R.
Zahalka, S.
Li, Q.
Randhawa, P.
Hoffman, R.A.
Ramaswami, B.
Lund, F.E.
Chalasani, G.
Issue Date: 3-Mar-2014
Citation: Zeng, Q., Ng, Y.-H., Singh, T., Jiang, K., Sheriff, K.A., Ippolito, R., Zahalka, S., Li, Q., Randhawa, P., Hoffman, R.A., Ramaswami, B., Lund, F.E., Chalasani, G. (2014-03-03). B cells mediate chronic allograft rejection independently of antibody production. Journal of Clinical Investigation 124 (3) : 1052-1056. ScholarBank@NUS Repository. https://doi.org/10.1172/JCI70084
Abstract: Chronic rejection is the primary cause of long-term failure of transplanted organs and is often viewed as an antibody-dependent process. Chronic rejection, however, is also observed in mice and humans with no detectable circulating alloantibodies, suggesting that antibody-independent pathways may also contribute to pathogenesis of transplant rejection. Here, we have provided direct evidence that chronic rejection of vascularized heart allografts occurs in the complete absence of antibodies, but requires the presence of B cells. Mice that were deficient for antibodies but not B cells experienced the same chronic allograft vasculopathy (CAV), which is a pathognomonic feature of chronic rejection, as WT mice; however, mice that were deficient for both B cells and antibodies were protected from CAV. B cells contributed to CAV by supporting splenic lymphoid architecture, T cell cytokine production, and infiltration of T cells into graft vessels. In chimeric mice, in which B cells were present but could not present antigen, both T cell responses and CAV were markedly reduced. These findings establish that chronic rejection can occur in the complete absence of antibodies and that B cells contribute to this process by supporting T cell responses through antigen presentation and maintenance of lymphoid architecture.
Source Title: Journal of Clinical Investigation
URI: http://scholarbank.nus.edu.sg/handle/10635/126788
ISSN: 00219738
DOI: 10.1172/JCI70084
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