Please use this identifier to cite or link to this item: https://doi.org/10.1586/1744666X.2013.811119
DC FieldValue
dc.titleInfectious and noninfectious triggers in Guillain-Barré syndrome
dc.contributor.authorWakerley, B.R.
dc.contributor.authorYuki, N.
dc.date.accessioned2016-09-06T08:19:39Z
dc.date.available2016-09-06T08:19:39Z
dc.date.issued2013
dc.identifier.citationWakerley, B.R., Yuki, N. (2013). Infectious and noninfectious triggers in Guillain-Barré syndrome. Expert Review of Clinical Immunology 9 (7) : 627-639. ScholarBank@NUS Repository. https://doi.org/10.1586/1744666X.2013.811119
dc.identifier.issn1744666X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126773
dc.description.abstractGuillain-Barré syndrome (GBS) is the commonest cause of acquired flaccid paralysis in the world and regarded by many as the prototype for postinfectious autoimmunity. Here the authors consider both infectious and noninfectious triggers of GBS and determine where possible what immunological mechanisms may account for this association. In approximately two-thirds of cases, an infectious trigger is reported in the weeks that lead up to disease onset, indicating that the host's response to infection must play an important role in disease pathogenesis. The most frequently identified bacteria, Campylobacter jejuni, through a process known as molecular mimicry, has been shown to induce cross-reactive anti-ganglioside antibodies, which can lead to the development of axonal-type GBS in some patients. Whether this paradigm can be extended to other infectious organisms or vaccines remains an important area of research and has public health implications. GBS has also been reported rarely in patients with underlying systemic diseases and immunocompromised states and although the exact mechanism is yet to be established, increased susceptibility to known infectious triggers should be considered most likely. © 2013 Informa UK Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1586/1744666X.2013.811119
dc.sourceScopus
dc.subjectacute inflammatory demyelinating polyneuropathy
dc.subjectacute motor axonal neuropathy
dc.subjectBickerstaff brainstem encephalitis
dc.subjectCampylobacter jejuni
dc.subjectFisher syndrome
dc.subjectGuillain-Barré syndrome
dc.subjectmolecular mimicry
dc.typeReview
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1586/1744666X.2013.811119
dc.description.sourcetitleExpert Review of Clinical Immunology
dc.description.volume9
dc.description.issue7
dc.description.page627-639
dc.identifier.isiut000337187700009
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

42
checked on Oct 17, 2019

WEB OF SCIENCETM
Citations

36
checked on Oct 17, 2019

Page view(s)

51
checked on Oct 11, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.