Please use this identifier to cite or link to this item: https://doi.org/10.1089/aid.2012.0174
Title: CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit
Authors: Kamiyama, H.
Kakoki, K.
Shigematsu, S.
Izumida, M.
Yashima, Y.
Tanaka, Y.
Hayashi, H.
Matsuyama, T.
Sato, H.
Yamamoto, N. 
Sano, T.
Shidoji, Y.
Kubo, Y.
Issue Date: 1-Feb-2013
Citation: Kamiyama, H., Kakoki, K., Shigematsu, S., Izumida, M., Yashima, Y., Tanaka, Y., Hayashi, H., Matsuyama, T., Sato, H., Yamamoto, N., Sano, T., Shidoji, Y., Kubo, Y. (2013-02-01). CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit. AIDS Research and Human Retroviruses 29 (2) : 279-288. ScholarBank@NUS Repository. https://doi.org/10.1089/aid.2012.0174
Abstract: Development of an effective low-cost anti-acquired immunodeficiency syndrome (AIDS) drugs is needed for treatment of AIDS patients in developing countries. Host cell lipid raft microdomains, which are enriched with cholesterol, glycolipids, ceramide, and gangliosides, are important for human immunodeficiency virus type 1 (HIV-1) entry. Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1. In this study, we found that the acyclic retinoid analogs geranylgeranoic acid (GGA) and NIK-333 as well as CT-B efficiently attenuate CXCR4-tropic, but not CCR5-tropic, HIV-1 vector infection. We also found that GGA and NIK-333 suppress CXCR4-tropic HIV-1 infection by attenuating CXCR4 expression. CT-B also attenuated CXCR4-tropic HIV-1 infection, but did not suppress CXCR4 expression. These results suggest a distinct role for lipid raft microdomains in CXCR4- and CCR5-tropic HIV-1 infections and illuminate novel agents for the development of AIDS therapy. © 2013 Mary Ann Liebert, Inc.
Source Title: AIDS Research and Human Retroviruses
URI: http://scholarbank.nus.edu.sg/handle/10635/126715
ISSN: 08892229
DOI: 10.1089/aid.2012.0174
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on Aug 17, 2019

WEB OF SCIENCETM
Citations

3
checked on Aug 9, 2019

Page view(s)

18
checked on Aug 16, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.