Please use this identifier to cite or link to this item: https://doi.org/10.7883/yoken.67.157
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dc.titleMolecular analysis of ciprofloxacin resistance among non-typhoidal Salmonella with reduced susceptibility to ciprofloxacin isolated from patients at a tertiary care Hospital in Kuala Lumpur, Malaysia
dc.contributor.authorKarunakaran, R.
dc.contributor.authorTay, S.T.
dc.contributor.authorRahim, F.F.
dc.contributor.authorLim, B.B.
dc.contributor.authorPuthucheary, S.D.
dc.date.accessioned2016-09-06T03:00:23Z
dc.date.available2016-09-06T03:00:23Z
dc.date.issued2014
dc.identifier.citationKarunakaran, R., Tay, S.T., Rahim, F.F., Lim, B.B., Puthucheary, S.D. (2014). Molecular analysis of ciprofloxacin resistance among non-typhoidal Salmonella with reduced susceptibility to ciprofloxacin isolated from patients at a tertiary care Hospital in Kuala Lumpur, Malaysia. Japanese Journal of Infectious Diseases 67 (3) : 157-162. ScholarBank@NUS Repository. https://doi.org/10.7883/yoken.67.157
dc.identifier.issn18842836
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126518
dc.description.abstractWe investigated the prevalence of non-typhoidal Salmonella (NTS) with "reduced susceptibility to ciprofloxacin" (RS-Cip) (minimum inhibitory concentration [MIC], 0.12-1.0 μg/mL) as well as their resistance genes in 75 NTS isolates (53 from stool, 21 from blood, and 1 from urine) from patients at a tertiary care Malaysian hospital between January and December 2009. RS-Cip was detected in 24/75 (32.0z) isolates. Using the ciprofloxacin MIC interpretive criteria for Salmonella in the Clinical and Laboratory Standards Institute 2013 guidelines, 51/75 (68.0z) isolates were found to be sensitive, 22/75 (29.3z) were intermediate, and 2/75 (2.7z) were resistant to ciprofloxacin. The 24 isolates that were intermediate or resistant to ciprofloxacin were the same isolates categorized as having RS-Cip. Among the 23 tested isolates with RS-Cip, the qnrS gene was detected in 17/23 (73.9z) and single gyrA mutations were detected in 6/23 (26.1z) (Asp87Tyr [n = 3], Asp87Asn [n = 2], and Ser83Phe [n = 1]). A parC (Thr57Ser) mutation was detected in 13/23 (56.5z) isolates, coexisting with either a qnrS gene or a gyrA mutation. The high incidence of the qnrS gene among isolates with RS-Cip needs to be monitored because qnr genes can spread via plasmids and aid in the emergence of increased resistance levels.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.7883/yoken.67.157
dc.sourceScopus
dc.subjectCiprofloxacin
dc.subjectMalaysia
dc.subjectMolecular analysis
dc.subjectNon-Typhoidal Salmonella
dc.subjectResistance
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.7883/yoken.67.157
dc.description.sourcetitleJapanese Journal of Infectious Diseases
dc.description.volume67
dc.description.issue3
dc.description.page157-162
dc.description.codenJJIDF
dc.identifier.isiut000336821700002
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