Please use this identifier to cite or link to this item: https://doi.org/10.1586/era.10.97
Title: Controversies and challenges in the current management of nasopharyngeal cancer
Authors: Tham, I.W.-K. 
Lu, J.J. 
Keywords: IMRT
intensity-modulated radiation therapy
nasopharyngeal carcinoma
radiation therapy
treatment
Issue Date: Sep-2010
Citation: Tham, I.W.-K., Lu, J.J. (2010-09). Controversies and challenges in the current management of nasopharyngeal cancer. Expert Review of Anticancer Therapy 10 (9) : 1439-1450. ScholarBank@NUS Repository. https://doi.org/10.1586/era.10.97
Abstract: Nasopharyngeal carcinoma is uncommon worldwide, but poses a significant public health burden in endemic regions. Primary treatment for nonmetastatic disease is by radiation therapy, which has evolved from simple 2D-planning techniques to intensity-modulated radiation therapy. The role of systemic therapy has also become more prominent, with concurrent cisplatin-based chemoradiation the current standard of care for locally advanced disease based on multiple Phase III studies. Based on these advances, the prognosis of nasopharyngeal carcinoma appears to have improved significantly over the past two decades. Nevertheless, there are areas of substantial uncertainty and divergent views in the optimal treatment strategy. Distant metastases have become the dominant mode of treatment failure with the excellent local control provided by intensity-modulated radiation therapy. Recent studies have focused on this challenge of treating micrometastases while keeping toxicities manageable. Radiation therapy techniques continue to be refined to maintain consistently high locoregional tumor control while decreasing the probability of acute and late toxicities. This article discusses some of the current issues confronting the multidisciplinary team managing this disease. © 2010 Expert Reviews Ltd.
Source Title: Expert Review of Anticancer Therapy
URI: http://scholarbank.nus.edu.sg/handle/10635/125844
ISSN: 14737140
DOI: 10.1586/era.10.97
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