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Title: An emerging role of PARK2 in cancer
Authors: Xu, L.
Lin, D.-C. 
Yin, D.
Koeffler, H.P. 
Keywords: Deletion
Tumor suppressor
Issue Date: Jan-2014
Citation: Xu, L., Lin, D.-C., Yin, D., Koeffler, H.P. (2014-01). An emerging role of PARK2 in cancer. Journal of Molecular Medicine 92 (1) : 31-42. ScholarBank@NUS Repository.
Abstract: PARK2 (PARKIN) is an E3 ubiquitin ligase involved in multiple signaling pathways and cellular processes. Activity of PARK2 is tightly regulated through inter- and intra-molecular interactions. Dysfunction of PARK2 is associated with the progression of parkinsonism. Notably, frequent PARK2 inactivation has been identified in various human cancers. Park2-deficient mice are more susceptible to tumorigenesis, indicating its crucial role as a tumor suppressor. However, biological studies also show that PARK2 possesses both pro-survival and growth suppressive functions. Here, we summarize the genetic lesions of PARK2 in human cancers and discuss the current knowledge of PARK2 in cancer progression. We further highlight future efforts for the study of PARK2 in cancer. © 2013 Springer-Verlag Berlin Heidelberg.
Source Title: Journal of Molecular Medicine
ISSN: 09462716
DOI: 10.1007/s00109-013-1107-0
Appears in Collections:Staff Publications

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