Please use this identifier to cite or link to this item:
Title: Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009
Authors: Xiang, Y.-T.
Buchanan, R.W.
Ungvari, G.S.
Chiu, H.F.K.
Lai, K.Y.C.
Li, Y.-H.
Si, T.-M.
Wang, C.-Y.
Lee, E.H.M.
He, Y.-L.
Yang, S.-Y.
Chong, M.-Y.
Kua, E.-H. 
Fujii, S.
Sim, K. 
Yong, M.K.H.
Trivedi, J.K.
Chung, E.-K.
Udomratn, P.
Chee, K.-Y.
Sartorius, N.
Tan, C.-H. 
Shinfuku, N.
Issue Date: 10-Jun-2013
Citation: Xiang, Y.-T., Buchanan, R.W., Ungvari, G.S., Chiu, H.F.K., Lai, K.Y.C., Li, Y.-H., Si, T.-M., Wang, C.-Y., Lee, E.H.M., He, Y.-L., Yang, S.-Y., Chong, M.-Y., Kua, E.-H., Fujii, S., Sim, K., Yong, M.K.H., Trivedi, J.K., Chung, E.-K., Udomratn, P., Chee, K.-Y., Sartorius, N., Tan, C.-H., Shinfuku, N. (2013-06-10). Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009. PLoS ONE 8 (6) : -. ScholarBank@NUS Repository.
Abstract: Background:To date there has been no large-scale international study that examined the use of clozapine in older patients with schizophrenia. This study examined the use of clozapine and its demographic and clinical correlates in older patients with schizophrenia in East Asia during the period between 2001 and 2009.Method:Information on 1,157 hospitalized patients with schizophrenia aged 50 or older in five East Asian countries and territories (China, Hong Kong, Korea, Singapore and Taiwan) was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) project. Socio-demographic and clinical characteristics and prescription of psychotropic medications were recorded.Results:Clozapine was prescribed for 20.6% of the pooled sample; 19.0% in 2001, 19.4% in 2004 and 22.9% in 2009. Multiple logistic regression analysis of the whole sample revealed that patients taking clozapine had a longer duration of illness, more negative symptoms and were less likely to receive first generation antipsychotic and anticholinergic drugs, but more likely to report weight gain compared to those not receiving clozapine. Compared to those in other sites, older patients in China were more likely to receive clozapine.Conclusions:The prescription of clozapine for older Asian schizophrenia inpatients has remained at a stable level during the past decade. The appropriateness of use of clozapine in China needs to be further explored. © 2013 Xiang et al.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0066154
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2013_Use_of_Clozapine_in_Older.PDF182.71 kBAdobe PDF



Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.