Please use this identifier to cite or link to this item: https://doi.org/10.1177/0004867412453625
DC FieldValue
dc.titleUse of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009)
dc.contributor.authorXiang, Y.-T.
dc.contributor.authorKreyenbuhl, J.
dc.contributor.authorDickerson, F.B.
dc.contributor.authorUngvari, G.S.
dc.contributor.authorWang, C.-Y.
dc.contributor.authorSi, T.-M.
dc.contributor.authorLee, E.H.
dc.contributor.authorHe, Y.-L.
dc.contributor.authorChiu, H.F.
dc.contributor.authorYang, S.-Y.
dc.contributor.authorChong, M.-Y.
dc.contributor.authorTan, C.-H.
dc.contributor.authorKua, E.-H.
dc.contributor.authorFujii, S.
dc.contributor.authorSim, K.
dc.contributor.authorYong, M.K.
dc.contributor.authorTrivedi, J.K.
dc.contributor.authorChung, E.-K.
dc.contributor.authorUdomratn, P.
dc.contributor.authorChee, K.-Y.
dc.contributor.authorSartorius, N.
dc.contributor.authorShinfuku, N.
dc.date.accessioned2016-07-08T09:29:58Z
dc.date.available2016-07-08T09:29:58Z
dc.date.issued2012-12
dc.identifier.citationXiang, Y.-T., Kreyenbuhl, J., Dickerson, F.B., Ungvari, G.S., Wang, C.-Y., Si, T.-M., Lee, E.H., He, Y.-L., Chiu, H.F., Yang, S.-Y., Chong, M.-Y., Tan, C.-H., Kua, E.-H., Fujii, S., Sim, K., Yong, M.K., Trivedi, J.K., Chung, E.-K., Udomratn, P., Chee, K.-Y., Sartorius, N., Shinfuku, N. (2012-12). Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009). Australian and New Zealand Journal of Psychiatry 46 (12) : 1159-1164. ScholarBank@NUS Repository. https://doi.org/10.1177/0004867412453625
dc.identifier.issn00048674
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125666
dc.description.abstractObjective: This study examined the prescribing patterns of several first- (FGAs) and second generation antipsychotic (SGAs) medications administered to older Asian patients with schizophrenia during the period between 2001 and 2009. Method: Information on hospitalized patients with schizophrenia aged 65 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (20012009). There were no older patients in Thailand, therefore data on 467 patients in eight Asian countries and territories including China, Hong Kong SAR, India, Japan, Korea, Malaysia, Singapore, and Taiwan were analysed. Cross-sectional socio-demographic data, clinical characteristics and antipsychotic prescriptions were assessed using a standardized protocol and data collection procedure. Results: Of the 467 patients, 192 patients (41.1%) received FGAs only, 166 (35.5%) received SGAs only and 109 (23.3%) received a combination of FGAs and SGAs. Of the FGAs, haloperidol was the most commonly used (31.3%; mean 9.4 ± 6.7 mg/day), followed by chlorpromazine (15.4%; mean 126.4 ± 156.4 mg/day) and sulpiride (6.6%; mean 375.0 ± 287.0 mg/day). Of the SGAs, risperidone was the most commonly used (31.5%; mean 4.5 ± 2.7 mg/day), followed by olanzapine (13.1%; mean 13.6 ± 6.5 mg/day), quetiapine (7.3%; mean 325.0 ± 237.3 mg/day) and aripiprazole (1.9%; mean 17.6 ± 7.7 mg/day). Conclusions: FGAs and higher doses of certain SGAs (risperidone, olanzapine and quetiapine) were still commonly dispensed to older Asian patients with schizophrenia. Considering older patients reduced tolerability of potentially severe side effects associated with FGAs and higher doses of certain SGAs, continuing education and training addressing the rational use of antipsychotics in this population is clearly needed. © 2012 The Royal Australian and New Zealand College of Psychiatrists.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1177/0004867412453625
dc.sourceScopus
dc.subjectAsia
dc.subjectolder patients
dc.subjectprescription patterns
dc.subjectschizophrenia
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1177/0004867412453625
dc.description.sourcetitleAustralian and New Zealand Journal of Psychiatry
dc.description.volume46
dc.description.issue12
dc.description.page1159-1164
dc.description.codenANZPB
dc.identifier.isiut000311884800007
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on Jul 31, 2020

WEB OF SCIENCETM
Citations

7
checked on Jul 31, 2020

Page view(s)

122
checked on Jul 31, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.