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Title: Serum soluble E-cadherin is a potential prognostic marker in esophageal squamous cell carcinoma
Authors: Chung, Y.
Law, S.
Kwong, D.L.W.
Luk, J.M. 
Keywords: Enzyme linked immunosorbent assay
Esophageal squamous cell carcinoma
Neoadjuvant chemoradiation therapy
Soluble E-cadherin
Issue Date: Jan-2011
Citation: Chung, Y., Law, S., Kwong, D.L.W., Luk, J.M. (2011-01). Serum soluble E-cadherin is a potential prognostic marker in esophageal squamous cell carcinoma. Diseases of the Esophagus 24 (1) : 49-55. ScholarBank@NUS Repository.
Abstract: E-cadherin is a well-documented tumor suppressor with downregulated expression in many cancer types. Upon proteolytic cleavage, a soluble form of 80-kDa degradation fragment, known as soluble E-cadherin (s-Ecad), is present in circulation; its level in sera of cancer patients is significantly associated with metastasis, recurrence, and prognosis in some malignancies. The present study investigated the association of s-Ecad with clinicopathological characteristics of patients with esophageal squamous cell carcinoma (ESCC) and its prognostic significance. A cohort of 97 patients who underwent surgery alone (n= 56) or neoadjuvant chemoradiation therapy and surgery (CRT) (n= 41) was recruited for this study. Serum samples were collected at operation (surgery group) and pre- and post-CRT treatment (CRT group) for measurement of s-Ecad protein by enzyme linked immunosorbent assay. Serum s-Ecad levels were correlated with clinicopathological parameters as well as survival. Univariate analysis showed no significant relationship between serum s-Ecad level and clinicopathological parameters for all sets of samples. Survival analysis showed that in patients who had surgical resection only, those with s-Ecad levels equal to or below the median value survived significantly longer than those with levels above the median (median survival 25.6 vs. 14.1 months, P= 0.012). Multivariate analysis showed that pathological N stage, M stage, R category, and serum s-Ecad level were significant independent prognostic factors for ESCC patients who underwent surgery only. The hazard ratio for s-Ecad was 1.104 (95% CI: 1.026-1.187) and P= 0.008. Serum s-Ecad was detected in ESCC patients and its potential as an independent prognostic marker requires further investigation. © 2010 © the Authors. Journal compilation © 2010, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.
Source Title: Diseases of the Esophagus
ISSN: 11208694
DOI: 10.1111/j.1442-2050.2010.01093.x
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