Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M110.181750
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dc.titleLipooligosaccharide of Campylobacter jejuni: Similarity with multiple types of mammalian glycans beyond gangliosides
dc.contributor.authorHouliston, R.S.
dc.contributor.authorVinogradov, E.
dc.contributor.authorDzieciatkowska, M.
dc.contributor.authorLi, J.
dc.contributor.authorSt Michael, F.
dc.contributor.authorKarwaski, M.-F.
dc.contributor.authorBrochu, D.
dc.contributor.authorJarrell, H.C.
dc.contributor.authorParker, C.T.
dc.contributor.authorYuki, N.
dc.contributor.authorMandrell, R.E.
dc.contributor.authorGilbert, M.
dc.date.accessioned2016-07-08T09:28:00Z
dc.date.available2016-07-08T09:28:00Z
dc.date.issued2011-04-08
dc.identifier.citationHouliston, R.S., Vinogradov, E., Dzieciatkowska, M., Li, J., St Michael, F., Karwaski, M.-F., Brochu, D., Jarrell, H.C., Parker, C.T., Yuki, N., Mandrell, R.E., Gilbert, M. (2011-04-08). Lipooligosaccharide of Campylobacter jejuni: Similarity with multiple types of mammalian glycans beyond gangliosides. Journal of Biological Chemistry 286 (14) : 12361-12370. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M110.181750
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125506
dc.description.abstractCampylobacter jejuni is well known for synthesizing ganglioside mimics within the glycan component of its lipooligosaccharide (LOS), which have been implicated in triggering Guillain-Barré syndrome. We now confirm that this pathogen is capable of synthesizing a much broader spectrum of host glycolipid/glycoprotein mimics within its LOS. P blood group and paragloboside (lacto-N-neotetraose) antigen mimicry is exhibited by RM1221, a strain isolated from a poultry source. RM1503, a gastroenteritis-associated strain, expresses lacto-N-biose and sialyl-Lewis c units, the latter known as the pancreatic tumor-associated antigen, DU-PAN-2 (or LSTa). C. jejuni GC149, a Guillain-Barré syndrome-associated strain, expresses an unusual sialic acid-containing hybrid oligosaccharide with similarity to both ganglio and Pk antigens and can, through phase variation of its LOS biosynthesis genes, display GT1a or GD3 ganglioside mimics. We show that the sialyltransferase CstII and the galactosyltransferase CgtD are involved in the synthesis of multiple mimic types, with LOS structural diversity achieved through evolving allelic substrate specificity.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M110.181750
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1074/jbc.M110.181750
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume286
dc.description.issue14
dc.description.page12361-12370
dc.description.codenJBCHA
dc.identifier.isiut000289077500050
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