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https://doi.org/10.1002/hed.23116
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dc.title | Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma | |
dc.contributor.author | Pan, J. | |
dc.contributor.author | Tang, T. | |
dc.contributor.author | Xu, L. | |
dc.contributor.author | Lu, J.J. | |
dc.contributor.author | Lin, S. | |
dc.contributor.author | Qiu, S. | |
dc.contributor.author | Chen, G. | |
dc.contributor.author | Tham, I.W.K. | |
dc.date.accessioned | 2016-07-08T09:27:02Z | |
dc.date.available | 2016-07-08T09:27:02Z | |
dc.date.issued | 2013-09 | |
dc.identifier.citation | Pan, J., Tang, T., Xu, L., Lu, J.J., Lin, S., Qiu, S., Chen, G., Tham, I.W.K. (2013-09). Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma. Head and Neck 35 (9) : 1238-1247. ScholarBank@NUS Repository. https://doi.org/10.1002/hed.23116 | |
dc.identifier.issn | 10433074 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/125438 | |
dc.description.abstract | Background The association between expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and the long-term outcomes in treated nasopharyngeal carcinoma (NPC) was studied. Methods Expression of COX-2, VEGF, and EGFR by immunohistochemical (IHC) staining was assessed in 128 patients with NPC. Overall survival (OS), disease-free survival (DFS), locoregional control, and distant metastasis-free survival rates were compared for different expression levels of each marker. Multivariate analysis was by the Cox regression model. Results Median follow-up after radiation therapy ± chemotherapy was 116 months. Univariate and multivariate analyses demonstrated that COX-2, VEGF, EGFR, and clinical stage were all independent predictors for OS, DFS, locoregional control, and distant metastasis-free survival rates. Conclusions High expression of COX-2, VEGF, and EGFR were independent adverse prognostic factors for long-term outcomes in nonmetastatic NPC independent of clinical stage. © 2012 Wiley Periodicals, Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/hed.23116 | |
dc.source | Scopus | |
dc.subject | cyclooxygenase 2 | |
dc.subject | epidermal growth factor receptor | |
dc.subject | nasopharyngeal neoplasms | |
dc.subject | prognosis | |
dc.subject | vascular endothelial growth factor | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1002/hed.23116 | |
dc.description.sourcetitle | Head and Neck | |
dc.description.volume | 35 | |
dc.description.issue | 9 | |
dc.description.page | 1238-1247 | |
dc.description.coden | HEANE | |
dc.identifier.isiut | 000323317000011 | |
Appears in Collections: | Staff Publications |
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